血小板增多对上皮性卵巢癌预后的影响  

Impact of Preoperative Thrombocytosis on the Prognosis of Patients with Primary Epithelial Ovarian Cancer

作　　者：庞晓燕[1] 张颐[1] 孟祥凯[1] 王化丽[2] 

机构地区：[1]中国医科大学附属第一医院妇科,沈阳110001 [2]大连市妇产医院妇产科,辽宁大连116033

出　　处：《中国医科大学学报》2014年第9期798-801,共4页Journal of China Medical University

基　　金：辽宁省自然科学基金(201202282)

摘　　要：目的探讨血小板增多在上皮性卵巢癌中的发生率及其对上皮性卵巢癌预后的影响。方法回顾性分析183例上皮性卵巢癌患者的临床资料,计算血小板增多的发生率,分析其与临床病理特征的关系,并比较合并血小板增多与无血小板增多患者生存时间的差异。结果 183例患者中51例(27.9%)合并血小板增多。血小板增多与上皮性卵巢癌的FIGO分期(P=0.001)、手术残留病灶(P=0.004)、术前血清CA125水平(P=0.040)及腹水量(P=0.010)均呈负相关,而与年龄、组织学分级、病理类型及深静脉血栓、肺栓塞的发生及其他血液检查指标无关(P>0.05)。合并血小板增多的上皮性卵巢癌患者无瘤生存时间(40和72个月,P=0.000)和总生存时间(60和86个月,P=0.001)均明显短于无血小板增多者。结论血小板增多是上皮性卵巢癌诊断时的常见现象,与肿瘤侵袭、进展及预后不良相关。Objective To evaluate the prevalence and prognostic value of preoperative thrombocytosis in patients with epithelial ovarian cancer （EOC） and to investigate its association with other elinicopathological features. Methods One hundred and eighty-three EOC patients were retro- spectively analyzed. Results Fifty-one of 183 （27.9%） patients showed thrombocytosis at primary diagnosis. Thrombocytosis was positively corre- lated with International Federation of Gynecology and Obstetrics （FIGO） stage （P = 0.001 ）, residual disease after primary surgery （P = 0.004）, CA125 level （P = 0.040） and volume of ascites （P = 0.010） but not with age, histotype, histological grade, postoperative deep vein thrombosis （DVT） or pulmonary embohsm （PE）, nor other haematological variables. Disease-free and overall survival time was significantly shorter in patients with thrombocytosis than those without thrombocytesis （ P = 0.000 and P = 0.001, respectively）. Conclusion Thrombocytosis is a frequent finding in patients with EOC at time of diagnosis and associated with poor prognosis.

关 键 词：血小板增多 血小板计数 上皮性卵巢癌 预后 

分 类 号：R737.31[医药卫生—肿瘤]