分子分型在乳腺癌术后复发转移中的应用研究  

Study on the Application of Molecular Subtypes in Postoperative Recurrence and Distant Metastasis of Breast Cancer

作　　者：董良[1] 李海金[1] 尚官敏[1] 葛丽娜[1] 

机构地区：[1]中国医科大学绍兴医院,浙江绍兴312030

出　　处：《肿瘤学杂志》2014年第9期715-719,共5页Journal of Chinese Oncology

摘　　要：[目的]研究乳腺癌分子分型与术后复发转移的关系。[方法]收集术后复发转移的乳腺癌患者的临床病理资料,明确患者复发转移的部位及时间,分析各分子亚型与临床病理特征以及复发转移部位、时间的关系。[结果]入组299例术后复发转移的乳腺癌患者,其中Luminal A型、Luminal B型、Her-2阳性型和Basal-like型分别为92例、79例、47例和81例。各分子亚型中年龄(P=0.034)、月经状况(P=0.013)、肿瘤组织学分级(P=0.000)、术后淋巴结转移情况(P=0.035)、术后复发转移时间(P=0.000)以及术后复发转移部位(P=0.007)存在显著差异。Cox逐步回归分析显示,组织学分级(P=0.000)和分子分型(P=0.000)是乳腺癌术后复发转移的独立预后因子。[结论]乳腺癌分子分型作为传统TNM分期的重要补充,能够很好地预测乳腺癌术后复发转移部位和时间,有助于临床医师对术后患者进行个体化随访筛查。[Purpose] To investigate the relationship of molecular subtypes with postoperative recurrence and distant metastasis of breast cancer. [Methods] The clinicopathologic data,the site and time of recurrence and metastasis were analyzed as well as the relationship of molecular subtypes with them. [Results] A total of 299 patients with breast cancer recurrence and distant metastasis postoperation were enrolled including Luminal A type 92 cases,Luminal B type 79 cases,Her-2 positive type 47 cases,and Basal-like type 81 cases. The distribution of age（P=0.034）,menstruation status（P=0.013）,histological differentiation（P=0.000）,axillary lymph nodes metastasis （P=0.035）,the time （P=0.000） and site （P=0.007） of recurrence and distant metastases in the four subtypes were significantly different. In the Cox regression analysis,the histological differentiation（P=0.000） and molecular subtype（P=-0.000） were independent prognos- tic factors of recurrence and distant metastases after surgery. [Conlusion] As an important complement for TNM staging,the molecular subtype of breast cancer can accurately assess the site and time of recurrence and distant metastases, and be helpful for individual screening of patients after surgery.

关 键 词：乳腺肿瘤 分子分型 远处转移 激素受体 人类表皮生长因子2(Her-2) 

分 类 号：R737.9[医药卫生—肿瘤]