前列腺癌组织BSP和PSA的表达及意义  

Expressions of Bone Sialoprotein and Prostate-specific Antigen in Prostate Cancer and Their Significance

作　　者：朱其聪[1] 毛高才[1] 吕扬[1] 王亚辉[1] 杨琳[1] 余书勇[1] 

机构地区：[1]解放军第一八七医院,海南海口571100

出　　处：《肿瘤学杂志》2014年第9期755-757,共3页Journal of Chinese Oncology

基　　金：海南省卫生基金资助项目(琼卫2011-98号)

摘　　要：[目的]探讨骨唾液酸蛋白(BSP)与前列腺特异性抗原(PSA)在前列腺癌组织中的表达及意义。[方法]选取不同病理分级的前列腺癌组织(68例)和前列腺增生组织(22例),采用免疫组织化学SP法染色,检测BSP及PSA的表达情况。[结果]BSP在前列腺癌中阳性率为76.47%,显著高于前列腺增生组织(13.64%)(χ2=27.614,P<0.001)。BSP在不同分化程度前列腺癌组织中表达差异无统计学意义(χ2=0.057,P=0.972)。前列腺增生组织、前列腺癌组织的PSA表达率分别为90.91%、69.12%,差异有统计学意义(χ2=4.149,P=0.042)。不同分化程度前列腺癌PSA表达差异有统计学意义(χ2=11.437,P=0.003)。BSP与PSA表达具有显著相关性(rs=0.654,P<0.001)。[结论]BSP在前列腺癌中高表达,与PSA表达相关。BSP可能在前列腺癌的发生、发展中起重要作用,可能成为前列腺癌治疗的新靶点。[Purpose] To investigate the expressions of bone sialoprotein （BSP） and prostate-specific antigen （PSA） in prostate cancer and their significance. [Methods] The expressions of BSP and PSA in 68 cases of prostate cancer with various pathological grading and in 22 cases with benign prostatic hyperplasia were detected immunohistochemically. [ Results ] The expression rate of BSP in prostate cancer （76.47%） was significantly higher than that in benign prostatic hyperplasia （13.64%）（χ^2=27.614, P〈0.001 ）. There was no significant difference of BSP expression in prostate cancer patients with various pathological grades （χ^2=0.057, P=0.972）. The expression rate of PSA in prostate cancer and in benign prostatic hyperplasia was 69.12% and 90.91% ,with sig- nificant difference between them （χ^2=4.149, P=0.042）. There was significant difference of PSA expression in prostate cancer patients with various pathological grades （χ^2=11.437 ,P=0.003）. Posi- tive correlation was found between BSP and PSA （r=0.654, P〈0.001 ）. [ Conclusion ] The high expression of BSP in prostate cancer is related to the expression of PSA.BSP may play an important role in the oneogenesis and progress of prostate cancer, and it may be as a new target for prostate cancer treatment.

关 键 词：前列腺肿瘤 骨唾液酸蛋白 前列腺特异性抗原 免疫组织化学 

分 类 号：R737.25[医药卫生—肿瘤]