无功能性胃肠胰神经内分泌肿瘤的临床特征和预后分析  

Analysis of Clinical Feature and Prognosis of Nonfunctional Gastroenteropancreatic Neuroendocrine Neoplasm

作　　者：丁丹红[1,2] 王修身[1,2] 卜珊珊[1,2] 宋志刚[1,2] 

机构地区：[1]郑州大学附属肿瘤医院 [2]河南省肿瘤医院,河南郑州450008

出　　处：《中国肿瘤》2014年第9期785-789,共5页China Cancer

摘　　要：[目的]探讨无功能性胃肠胰神经内分泌肿瘤的临床病理特征,并分析影响其预后的因素。[方法]回顾性分析河南省肿瘤医院2004年7月至2012年5月收治的73例无功能性胃肠胰神经内分泌肿瘤临床资料。[结果]全组患者的3、5年生存率分别为76.9%和40.5%。其中神经内分泌瘤(NET)、神经内分泌癌(NEC)、混合型腺—神经内分泌癌(MANEC)的3年和5年生存率分别为87.5%和50.0%、29.0%和18.1%、40.6%和10.2%。单因素分析显示年龄、性别、病理类型、TNM分期、发病部位和治疗方式是影响预后的因素。Cox多因素分析显示TNM分期和性别是影响预后的独立因素。[结论]女性、年轻、临床分期早、肿瘤级别低是影响无功能性胃肠胰神经内分泌肿瘤预后的有利因素。TNM分期和性别是影响预后的独立因素。[Purpose] To investigate the clinical feature and prognosis of nonfunctional gastroenteropancreatic neuroendocrine neoplasm（NF-GEP-NEN）. [Methods] The data of 73 patients with NFGEP-NEN treated in Henan Cancer Hospital from July 2004 to May 2012 were retrospectively reviewed. [Results] The 3-year and 5-year survival rates were 76.9% and 40.5% respectively in enrolled patients. The 3-year and 5-year survival of NET,NEC and MANEC were 87.5% and 50.0%,29.0% and 18.1%,40.6% and 10.2% respectively. Single-factor analysis showed that age,gender,pathological type,TNM stage,tumor location and treatment method were the factors affecting prognosis of patient with NF-GEP-NEN. Cox multivariate analysis revealed that TNM stage and gender significantly affected prognosis of NF-GEP-NEN. [Conclusions] Women,young,early clinical stage and low grade tumor are the favorable factors in patient with NF-GEP-NEN. TNM staging and gender were the independent prognostic factors.

关 键 词：胃肠道 胰腺 神经内分泌肿瘤 预后 

分 类 号：R736[医药卫生—肿瘤]