卵巢癌肠道转移的危险因素及预后分析  

An Analysis of Prognosis and Risk Factors of Ovarian Cancer with Intestinal Tract Metastasis

作　　者：邵婷[1] 陈秀玮[1] 张宗瑧 王树香[1] 张瑜[1] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院,黑龙江哈尔滨150081

出　　处：《中国肿瘤》2014年第9期790-794,共5页China Cancer

基　　金：黑龙江省自然科学基金项目(H201336)

摘　　要：[目的]分析卵巢癌肠道转移的危险因素。[方法]回顾性分析2005年6月至2008年6月经手术治疗的235例晚期卵巢恶性肿瘤病例的临床资料,经术后病理证实肠道转移者107例。[结果]吸烟、体重指数>30kg/m2、肿瘤直径>4cm、原发肿瘤累及两侧卵巢、临床分期较晚、组织分化较差、伴有大量腹水(≥1500ml)、CA125较高(≥500U/ml)与卵巢癌肠道转移有关(P<0.05)。转移肠段切除患者3年和5年生存率分别为57.7%和43.8%,肿瘤局部切除患者3年和5年生存率分别为30.4%和12.2%,两组3年和5年生存率差异有统计学意义(P<0.05)。残余病灶≥2cm的患者半年内复发率(54.5%)比残余病灶<2cm患者(18.8%)高(P<0.05),首次切除的患者半年内复发率(24.4%)比两次或以上切除患者(55.2%)低(P<0.05)。[结论]为提高卵巢癌肠道转移者疗效,术前应全面分析肠道转移的危险因素,评估肠道受累程度,做好充分的肠道准备;术中行肿瘤细胞减灭术应尽量采取转移肠道切除术。[Purpose] To investigate the risk factors of ovarian cancer with intestinal tract metastasis.[Methods] The data of 235 cases with advanced primary ovarian cancer after surgical treatment from June 2005 to June 2008 were retrospectively analyzed,107 cases were pathologically proven with intestinal tract metastasis.[Results] Smoking,body mass index 30kg/m2,tumor diameter4cm,primary tumors involving both ovaries,advanced stage,poor differentiation,large volume ascites（≥1500ml）and higher CA125（≥500U/ml） were associated with ovarian cancer with intestinal metastasis（P0.05）.The 3-,5-year survival was 57.7%,43.8% in patient with metastatic intestinal resection; and 30.4%,12.2% in patient with local tumor resection respectively. The half-year recurrence rate in residual lesion ≥2cm patients was significantly higher than that in residual lesion 2cm patients（54.5% vs18.8%,P0.05）. The half-year recurrence rate in once resection was significantly lower than that in multiple rescetion cases（24.4% vs 55.2%,P0.05）. [Conclusion] In order to improve the efficacy in ovarian cancer with intestinal tract metastasis,risk factors of intestinal metastasis and the extent of intestinal involvement should be comprehensively evaluated,full preparation of bowel should be made. Intraoperative cytoreductive surgery should be taken to transfer the intestinal resection.

关 键 词：卵巢癌 肠段转移 危险因素 预后 

分 类 号：R737.31[医药卫生—肿瘤]