P物质测定在小儿原发性肠套叠中的临床意义  

Effect of Substance P in the Infant Primary Intussusception

作　　者：苏蕊 王永森 

机构地区：[1]河北省传染病医院,河北沧州061001

出　　处：《现代检验医学杂志》2014年第4期157-158,162,共3页Journal of Modern Laboratory Medicine

基　　金：沧州市科学技术研究与发展指导计划（09ZD34）.

摘　　要：目的 通过检测P物质（SP）在小儿原发性肠套叠及其诱发因素（腹泻、饮食改变、上呼吸道感染等）存在时的变化情况,探讨SP的测定在小儿原发性肠套叠发病过程中的临床意义.方法 以2012年1～6月期间于沧州市中心医院住院治疗的肠套叠患儿39例（肠套叠患儿组）,及同期、同院的有饮食改变、腹泻、上呼吸道感染等肠套叠诱发因素的患儿30例（肠套叠诱因组）为研究对象,以同期健康幼儿30例为对照（对照组）,采用放射免疫方法检测肠套叠患儿组发病当时和空气灌肠复位后15日的血浆SP水平,同时检测肠套叠诱因组及对照组幼儿的血浆SP水平,并作比较、分析.结果 ①肠套叠患儿组血浆SP在肠套叠急性期水平（64.887±32.470 pg/ml）较对照组（41.362±24.362 pg/ml）明显升高,差异有统计学显著性意义（q检验,Q=4.777,P＜0.01）,15日后SP水平（50.060±26.083 pg/ml）较发病时明显下降,前后比较差异有统计学显著性意义（配对t检验,T=4.661,P＜0.01）,15日下降后的SP水平与对照组比较差异无统计学意义（q检验,Q=1.766,P＞0.05）.②肠套叠诱因组血浆SP水平（59.780±30.567 pg/ml）与对照组比较差异有统计学显著性意义（q检验,Q=3.517,P＜0.05）.③肠套叠患儿组中发病前有明确诱因存在者SP水平（72.172±33.352 pg/ml）与无明显诱因存在者（51.879±29.371 pg/ml）差异有统计学显著性意义（t检验,T=1.899,P＜0.05）.结论 腹泻、饮食改变、上呼吸道感染等可引发血浆SP升高,而升高的SP促进了肠套叠的发生、发展,肠套叠疾病的急性期SP达到了一个较高的水平,这可能是上述诱发因素诱发肠套叠的部分机制.Objective By detecting the plasma levels of substance P （SP） in the infants who were subjecting infant primary intussusception disease the factors such as alvi profluvium,changing of diet,upper respiratory infection which maybe induce intussusceptions,so that can kown the clinical significance of detecting SP.Methods From January 2012 to June,the testing group were collected from the infants who were subj ecting infant primary intussusception disease,and another testing group was the infants who subject the induced infactors;the controlled group were collected from the normal infants.Blood samples were taken from these infants.For the infants who were subjected infant primary intussusception disease,blood samples were taken again after 15 days since they were air enema reattached.Use the radioimmunoassay method to detect the plasma levels of SP,then compare the differences of them.Results In the testing group,the plasma levels of SP （64.887±32.470 pg/ml）in infants who were subjecting infant primary intussusception disease were higher than that of the normal infants （Q =4.777,P＜0.01）,after air enema reattachment 15 days （50.060 ± 26.083 pg/ml） they had be quickly declined （T=4.661,P＜0.01）.The plasma levels of SP （59.780±30.567 pg/ml） in infants who were subjecting the induced factors were higher than that of the normal infants （Q=3.517,P＜0.05）.In the testing group,the plasma levels of SP （72.172 ± 33.352 pg/ml） in the infants who had the induced factors before they were disease were higher than that （51.879±29.371 pg/ml） in the infants who had no the factors （Q=3.517,P＜0.05）.Conclusion The induced factors can induce the higher levels of SP of plasma and the higher levels of SP of plasma can induce a higher occurrence of infant primary intussusception,maybe this is one of reasons that the induced factors can lead to intussusception.

关 键 词：肠套叠 胃肠激素 P物质 放射免疫 

分 类 号：R574.3[医药卫生—消化系统] R392.11[医药卫生—内科学]