阿托伐他汀对急性脑梗死患者疗效及机制的探讨  

Effect of Atorvastatin Calcium on Acute Cerebral Infarction

作　　者：吴雅丽[1] 

机构地区：[1]首都医科大学石景山教学医院北京市石景山医院,北京100043

出　　处：《中外医学研究》2014年第25期22-23,共2页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:观察阿托伐他汀对脑梗死患者预后的影响及其血清C-反应蛋白(C-reactive protein,CRP)的变化。方法:将80例急性脑梗死患者随机分为对照组(40例)及治疗组(40例),两组均给予抗血小板聚集、控制血压、血糖及改善循环等常规治疗,治疗组在常规治疗基础上加用阿托伐他汀20 mg,每晚一次,观察共14 d。在治疗前及治疗后14 d采用美国国立卫生研究院卒中量表(NIHSS)评定患者神经功能缺损程度和测定血清C-反应蛋白含量,评价其疗效,并探讨其可能机制。结果:治疗组患者CRP降低,NIHSS评分有所改善。结论:阿托伐他汀治疗使脑梗死患者CRP水平明显下降,并能改善其的神经功能缺损,有明显的神经保护作用。Objective：To observe the efficacy of Atrovastatin on acute cerebral infarction and its influence on C-reactive protein.Method：80 patients with acute cerebral infarction were randomly divided into the control group（n=40） and the treatment group（n=40）.Two groups were treated with conventional therapy,and on the basis of conventional therapy the treatment group was treated with atrovastatin.The patients were given the neurological function evaluation with NIHSS and determination of C-reactive protein content to evaluate its clinical efficacy and explore its possible mechanism.Result：The improvement of neurological function in the treatment group was better compared with that in the control group.The treatment group C-reactive protein decreased significantly compared with the control group.Conclusion：Atorvastatin can significantly decreased the level of CRP in patients with cerebral infarction,and can improve the nerve function deficiency, has a significant neuroprotective effect.

关 键 词：阿托伐他汀 脑梗死 C-反应蛋白 

分 类 号：R743.3[医药卫生—神经病学与精神病学]