微波辅助高效合成N,O供体型杂环化合物(英文)  

Efficient synthesis of involving nitrogen- oxygen donor macrocyclic compounds by microwave- assisted witting reaction

作　　者：袁泽利[1] 余光勤[1] 罗玉兰[1] 宋文婷[1] 

机构地区：[1]遵义医学院药学院,贵州遵义563099

出　　处：《遵义医学院学报》2014年第4期366-368,共3页Journal of Zunyi Medical University

基　　金：国家自然科学基金资助项目(NO:81360471);贵州省自科科学基金资助项目(NO:[2011]2032);国家级大学生创新训练计划项目;贵州省大学生创新训练项目(NO:201310661001)

摘　　要：目的寻求具有药理活性的N,O供体型杂环化合物的高效合成方法。方法采用微波辅助和传统合成法对比合成N,O供体型杂环化合物。并利用1H NMR、13CNMR、FT-IR等现代分析手段对其结构进行鉴定。结果与传统方法相比,微波法能简便、快速、高效地合成N,O供体型杂环化合物。结论为N,O供体型杂环药物分子的合成提供了一条高效的新途径。Objective To discover the new synethetic method of nitrogen-oxygen donor macrocyclic compounds.Methods The title compounds were tested in the comparative trials with microwave irradiation and conventional heating.They were characterized by a combination of 1H NMR,13C NMR and FT-IR spectral.Results To compare with conventional method,microwave irradiation has some advantages such as fast,simple and efficient for synthesis of nitrogen-oxygen donor macrocyclic compounds.Conclusion This work provides an efficient methodology for the synthesis of nitrogen-oxygen donor macrocyclic compounds.

关 键 词：微波辅助合成 N O供体 大环化合物 

分 类 号：R914[医药卫生—药物化学]