非酒精性脂肪性肝病与代谢综合征相关性研究  

Relations between nonalcoholic fatty liver disease and metabolic syndrome

作　　者：胡卫[1] 张苗旋 谭金海[1] 

机构地区：[1]武汉大学医院,430072

出　　处：《中华流行病学杂志》2014年第9期1062-1064,共3页Chinese Journal of Epidemiology

摘　　要：目的 分析非酒精性脂肪性肝病（NAFLD）与MS的相关性.方法 2010-2011年对武汉大学医院在校教职工体检包括询问病史、体格检查、生化检查、肝脏彩超检查.按NAFLD诊断标准将研究对象分为NAFLD组和非NAFLD组,对两组与MS及其相关因素进行比较分析.结果 （1） NAFLD总患病率为20.7％,MS为13.3％,NAFLD组BMI、SBP、DBP、TG、FPG均较非NAFLD组高,HDL-C水平低于非NAFLD组（P＜0.001）.（2）NAFLD组MS患病率、肥胖患病率、高血糖异常率、高血压率、血脂异常率均高于非NAFLD组,且差异有统计学意义（P＜0.001）.（3）NAFLD组具有1～4个MS诊断指标的风险是非NAFLD组的1.66、4.22、8.72和25.62倍,差异均有统计学意义（P＜0.001）.结论 武汉大学教职工体检人群中NAFLD患者的MS及其危险因素发生率均高于非NAFLD患者,NAFLD与MS密切相关.Objective To analyze the relation between nonalcoholic fatty liver disease （NAFLD） and metabolic syndrome （MS） among adults from the Functional University Society （FUS）.Methods This survey was conducted among the staff of Wuhan University who underwent physical check-ups from 2010 to 2011 at the Affiliated Hospital of Wuhan University.The participants had records related to medical history,clinical examination,anthropometry,laboratory tests and routine liver ultrasonography.According to the diagnostic criteria of NAFLD,the cases were divided into two groups—with NAFLD or without.MS and its relevant risk factors of the two groups were compared.Results 1） The prevalence rates of nonalcoholic fatty liver disease and MS were 20.7%,and 13.3%,respectively.People with nonalcoholic fatty liver disease had higher levels of BMI,SBP,DBP,TG,FPG and lower level of HDL-C than those who did not have the problem.2） The risks of NAFLD group in developing MS,obesity,hypertension and dyslipidemia were higher than the non-group （P〈0.001）.3） The NAFLD group had 1.66,4.22,8.72 and 25.62 times chances of having 1 to 4 risk factors on MS than those without NAFLD.Conclusion NAFLD was closely associated with MS and its relevant risk factors.

关 键 词：非酒精性脂肪性肝病 代谢综合征 相关性分析 

分 类 号：R575.5[医药卫生—消化系统]