复方半边莲煎剂的化学成分研究  

Study on Chemical Constituents in Compound Lobelia Chinensis

作　　者：石磊[1] 姬志强[1] 康文艺[2] 

机构地区：[1]解放军第155中心医院,河南开封475003 [2]河南大学中药研究所,河南开封475004

出　　处：《中国药房》2014年第35期3308-3310,共3页China Pharmacy

基　　金：河南省科技厅重点攻关项目(No.122102310272);开封市社会发展科技攻关计划(No.120306)

摘　　要：目的：研究复方半边莲煎剂的化学成分。方法：采用薄层色谱法、硅胶色谱法、凝胶柱色谱法对复方半边莲煎剂进行分离纯化,通过理化方法和波谱数据进行结构鉴定。结果：从复方半边莲煎剂中分离得到6个化合物,通过理化性质及波谱数据分析,分别鉴定为芹菜素-7-O-β-d-葡糖苷（1）、没食子酸（2）、木犀草素-7-O-β-d-葡糖苷（3）、橙皮苷（4）、正丁基-α-d-呋喃果糖苷（5）和正丁基-β-d-呋喃果糖苷（6）。结论：化合物1~6均为首次从复方半边莲煎剂中分离得到。OBJECTIVE：To study the chemical constituents in Compound Lobelia chinensis decoction. METHODS：The compounds were isolated from Compound L. chinensis decoction and purified by TLC,silica gel and gel column chromatography. The structures were elucidated by physicochemical properties and spectral analysis. RESULTS：6 compounds were obtained and elucidated as apigenin-7-O-β-d-glucoside（1）,gallic acid（2）,luteolin-7-O-β-d-glucoside（3）,hesperidin（4）,n-butyl-α-d-fructofuranoside（5）and n-butyl-β-d-fructofuranoside（6）by physicochemical properties and spectral analysis. CONCLUSIONS：Compounds 1-6are isolated from Compound L. Chinensis decoction for the first time.

关 键 词：复方半边莲煎剂 化学成分 没食子酸 橙皮苷 

分 类 号：R284.1[医药卫生—中药学] R914[医药卫生—中医学]