LASEK、TransPRK治疗中低度近视的对比性观察  

Comparative Observation of LASEK, TransPRK Treatment of Low to Moderate Myopia

作　　者：常征[1] 曾凡超[1] 熊露[2] 

机构地区：[1]深圳爱尔眼科医院,广东深圳518032 [2]广州爱尔眼科医院,广东广州510080

出　　处：《中国医药指南》2014年第25期1-3,共3页Guide of China Medicine

基　　金：广州市越秀区科技计划项目(2010-WS-020)

摘　　要：目的对比观察准分子激光上皮瓣下角膜磨镶术(LASEK)、经角膜上皮准分子激光角膜切削术(TransPRK)治疗中低度近视的临床疗效。方法收集2013年1月至2013年12月在我院行准分子激光角膜表层切削术的患者50例(100眼),年龄20~38岁,等效球镜-1.25D^-5.75D,随机分配一只眼采用准分子激光去除上皮(50眼),另一眼采用20%酒精去除上皮(50眼),所有手术眼的基质切削均采用VISX准分子激光SurfacePRK模式,52%的患者使用MMC。术后随访半年,主要观察项目包括术后等效球镜屈光度、术后裸眼视力(UCVA)、术后刺激症状持续时间、上皮恢复时间等,结合各项观察数据对两种手术方式的疗效开展评价与对比。结果 t-PRK与LASEK的术前期望屈光度矫正量与实际屈光度矫正量均无统计学意义。两种术式术前最佳矫正视力无统计学意义,术后裸眼视力分别为(0.0385±0.0755)和(0.0662±0.0909),差异具有统计学意义(P<0.05);术后刺激症状持续时间(1.980±0.6141,2.580±0.5566)及角膜上皮修复时间(2.610±0.6332,3.460±0.7944),差异均具有统计学意义(P=0.000)。结论应用VISX准分子激光机行t-PRK和LASEK手术治疗中低度近视的屈光度矫正疗效无明显差异;t-PRK术后裸眼视力比术前最佳矫正视力更好,较LASEK术后裸眼视力更好,刺激症状持续时间更短,角膜上皮修复更快。Objective To compare clinical efficacy following Laser epithelial keratomileusis（LASEK）, transepithelial photorefractive keratectomy（TransPRK） in the treatment of low to moderate myopia. Methods We included 100 eyes of 50 patients, aged 20 to 38 years old, spherical equivalent refraction-1.25 D ～-5.75 diopters（D）, that underwent excimer laser surgery at our hospital from January 2013 to December 2013. Randomly assigned an eye using Laser epithelial keratomileusis（LASEK）, another one with 20% alcohol to remove epithelium（TransPRK）, all surgical eye stroma cutting using VISX excimer laser SurfacePRK mode, 52% of patients with mitomycin C（MMC）. All the patients were followed up for six months, the main observation items included postoperative spherical equivalent diopters,postoperative visual acuity（UCVA）, postoperative stimulus duration of symptoms and epithelial recovery time. Combined with the observation data, evaluated and compared the effects of two operation methods. Applied paired t-test analysis of the difference, P〈0.05 was considered statistically significance.Results Preoperative expectations diopter correction of TPRK and LASEK were（3.9188±1.2076D）,（4.0592±1.0348D）, t=-1.047, P〉0.05,respectively. the effective refraction correction were（4.1252±1.2894D）,（4.2480±1.1627D）,（t=-0.802, P〉0.05）, preoperative and postoperative differences were not statistically significant. Based on the preoperative best corrected visual acuity（0.0649±0.0942）,（0.0579±0.0775）,（t=0.955, P〉0.05） differences have no statistically significant, postoperative uncorrected visual acuity（0.0385±0.0755）,（0.0662±0.0909）,（t=-2.520, P〈0.05）, showed significant difference; postoperative stimulus duration of symptoms（1.980±0.6141,2.580±0.5566, t=-7.799, P〈0.0001） and corneal epithelial healing time（2.610±0.6332, 3.460±0.7944, t=-9.047, P〈0.0001）, the differences were statistically significant. Conclusions The differences of diopter corre

关 键 词：近视眼 屈光手术 准分子激光 经上皮准分子激光屈光性角膜切削术 

分 类 号：R778.11[医药卫生—眼科]