慢性萎缩性胃炎胃络瘀阻证与血清环氧化酶-2及胃黏膜病变程度的相关性  

The Relationship between Blood Stagnation in Gastric and Cox-2 as well as Pathology in Chronic Atrophic Gastritis

作　　者：杭海燕[1] 刘福生[1] 李培彩[1] 张寅[1] 陈亮[1] 刘婷[1] 苏泽琦[1] 朱辰辰 王晓迪[1] 王龙华[1] 丁霞[2] 

机构地区：[1]北京中医药大学东直门医院,北京100700 [2]北京中医药大学,北京100029

出　　处：《中国医药指南》2014年第25期4-5,共2页Guide of China Medicine

基　　金：国家自然科学基金项目(91129714;81270466);北京中医药大学自主选题(2013-JYB22-XS-141;2014-JYBZZ-JS-038)

摘　　要：目的探讨慢性萎缩性胃炎(CAG)胃络瘀阻证与血清环氧化酶-2(Cox-2)及胃黏膜病变程度的相关性。方法选择经电子胃镜、病理检查确诊为CAG患者,根据中医证型分为胃络瘀阻证和脾胃虚寒证的患者各30例,采用酶联免疫吸附实验(ELISA)的方法检测患者血清Cox-2的表达水平,分析CAG患者胃络瘀阻证与Cox-2及胃黏膜病变程度的相关性。结果 CAG胃络瘀阻证患者血清Cox-2表达水平高于脾胃虚寒证患者,差异有统计学意义(P<0.05);CAG胃络瘀阻证患者的胃黏膜病变程度比脾胃虚寒证患者的病变程度较重,差异有统计学意义(P<0.05)。结论 CAG患者胃络瘀阻证与Cox-2表达水平及胃黏膜病变程度之间具有一定的相关性,为中医药活血化瘀治疗CAG提供了依据。Objective To discuss the relationship between Blood Stagnation in Gastric and cyclooxygenase-2（Cox-2） as well as pathology in chronic atrophic gastritis（CAG）. Method 60 CAG patients made definitely diagnosis by electronic gastroscopy and pathological examination were divided into two groups. One group is 30 patients of Blood Stagnation in Gastric, and the other group is 30 patients of deficiency in the spleen and stomach with cold manifestations. The serum Cox-2 of patients was detected by enzyme-linked immunosorbent assay（ELISA）. Then analysis the serum Cox-2 as well as pathology differences between the two groups. Results Compared with the spleen and stomach with cold manifestations group, the serum Cox-2 is higher and the gastric pathology grade is more serious in Blood Stagnation in Gastric group（P〈0.05）. Conclusion There are some relationships between Blood Stagnation in Gastric and Cox-2 as well as pathology in chronic atrophic gastritis,which may provide a certain basis for treatment of CAG by activating blood circulation.

关 键 词：慢性萎缩性胃炎 胃络瘀阻证 环氧化酶-2 胃黏膜病理 

分 类 号：R573.3[医药卫生—消化系统]