IL-1B基因多态性及幽门螺旋杆菌感染与胃癌的关系研究  

Study on the Relationship of IL-1B Gene Polymorphism and Helicobacter Pylori Infection with Gastric Cancer

作　　者：张军喜 段广才[2] 郭爱叶[3] 柴健 马颖辉 董玮 

机构地区：[1]河南省人口和计划生育科学技术研究院,河南郑州450002 [2]郑州大学公共卫生学院 [3]河南省人民医院

出　　处：《中国医学创新》2014年第27期1-3,共3页Medical Innovation of China

基　　金：河南省科技厅科技攻关项目基金课题(0424410035)

摘　　要：目的:探讨IL-1B基因多态性与胃癌易感性的关系。方法:以聚合酶链反应-限制性片段长度多态性(PCR-RFLP)分析法检测65例胃癌患者和130例非胃癌患者的IL-1B基因位点多态性。结果:IL-1B-31及IL-1B-511均有3种基因型,分别是C/C、C/T和T/T;病例组Hp阳性感染率(70.8%)高于对照组(55.4%),差异有统计学意义(字2=5.6,P<0.05)。Hp感染时,IL-1B-511和IL-1B-31的T/T均能增加胃癌发病的风险,OR分别为8.1(95%CI:2.4-10.1)和11.5(95%CI:1.9-13.1)。结论:IL-lB-31和-511 TT基因多态性与河南地区胃癌的发生有关。Objective：To investigate the correlation of the polymorphisms of the IL-1B gene with the susceptibility of gastric cancer.Method：The genetic DNA was extracted from the peripheral blood of 130 normal subjects and 65 gastric cancer patients in Henan Province.IL-1 polymorphisms were analyzed using PCR-restriction fragment length polymorphism.Result：IL-1B-31 and IL-1B-511 were 3 genotypes,respectively was C/C,C/T and T/T;the rate of Hp infection（55.4%）in control was lower than cases（70.8%）,and there was significant difference（χ2=5.6,P〈0.05 ）.IL-1B-511 and IL-1B-31T/T could increase the risk of gastric cancer OR=8.1（95%CI：2.4-10.1）,OR=11.5（95%CI：1.9-13.1）.Conclusion：IL-1B-31 and IL-1B-511 TT gene polymorphism may be associated with the risk of gastric cancer in this area.

关 键 词：白细胞介素-1 基因多态性 胃癌 

分 类 号：R735.2[医药卫生—肿瘤]