评价肿瘤体积与淋巴结转移率比值作为Ⅲ期结直肠癌复发、转移指标的价值  

Tumor volume and lymph node metastasis ratio as a recurrence and metastasis index of stage Ⅲ colorectal cancer

作　　者：姚蒙洁 宁宁[1,2] 杜晓辉[1,2] 薛虎臣[1] 刘海亮[1] 徐迎新[1] 

机构地区：[1]解放军总医院普通外科研究所,北京100853 [2]解放军总医院普通外科,北京100853

出　　处：《解放军医学院学报》2014年第10期984-986,1018,共4页Academic Journal of Chinese PLA Medical School

基　　金：国家自然科学基金项目(61170123;81172897)~~

摘　　要：目的评价肿瘤体积与淋巴结转移率(lymph nodes metastasis ratio,LNR)的比值作为Ⅲ期结直肠癌复发、转移指标的临床价值。方法对2005年6月-2008年6月在本院普通外科行结直肠癌根治术的120例Ⅲ期结直肠癌患者临床资料进行分析,依据肿瘤是否复发、转移将120例结直肠癌患者分为无瘤生存组和肿瘤转移组,并进行随访分析。结果单因素分析结果显示,阳性淋巴结数(P=0.037)、LNR(P=0.002)、N分期(P=0.045)和TN比值(P=0.038)与结直肠癌术后复发、转移具有相关性,差异有统计学意义。多因素分析结果显示TN比值(P=0.028)、LNR(P=0.029)和N分期(P=0.002)均为影响结直肠癌术后复发、转移的独立相关因素。结论 TN比值具有独立的近期预后作用,可作为Ⅲ期结直肠癌术后肿瘤复发、转移的重要评价指标。Objective To study the tumor volume and lymph node metastasis ratio as a recurrence and metastasis index of stage Ⅲ colorectal cancer （CRC）. Methods Clinical data about 120 stage Ⅲ CRC patients who underwent radical operation in our hospital from June 2005 to June 2008 were retrospectively analyzed. The patients were divided into tumor-free survival group and tumor metastasis group and followed up. Results Univariate analysis showed that the number of positive lymph nodes, lymph node ratio （LNR）, N stage and TN ratio were related with the recurrence and metastasis of stage Ⅲ CRC （P 〈 0.05）. Multivariate regression analysis showed that TN ratio, LNR and N stage were the independent factors for the recurrence and metastasis of stage Ⅲ CRC. Conclusion The TN ratio is an independent factor for the early prognosis of stage Ⅲ CRC, and can thus be used as an important index for the recurrence and metastasis of stage Ⅲ CRC after operation.

关 键 词：结直肠癌 肿瘤体积 淋巴结转移率 复发 转移 

分 类 号：R735.35[医药卫生—肿瘤]