轻度认知障碍患者脑脊液中β-淀粉样蛋白42及磷酸化Tau蛋白的水平检测及意义  

Significance and detection of Aβ42 and P-tau levels in CSF of patients with mild cognitive impairment

作　　者：韩丽珠[1] 王文静[1] 褚忠海 吴元波[1] 吴蕾[1] 程昭昭[1] 孙安源[2] 

机构地区：[1]安徽医科大学附属省立医院神经内科,合肥市230001 [2]安徽医科大学附属省立医院检验科,合肥市230001

出　　处：《实用医学杂志》2014年第19期3079-3081,共3页The Journal of Practical Medicine

基　　金：2013年安徽省卫生厅医学科研课题(编号:13zc032)

摘　　要：目的:探讨轻度认知障碍(MCI)患者脑脊液中β-淀粉样蛋白42(Aβ42)与磷酸化Tau蛋白(P-tau)水平变化及其意义。方法:采用ELISA法检测25例MCI患者和14例认知功能正常者脑脊液标本中Aβ42和P-tau水平,并对MCI患者脑脊液中P-tau和MMSE评分进行相关统计学分析。结果:MCI组脑脊液中Aβ42水平低于对照组,P-tau水平高于对照组,差异有统计学意义(P<0.05)。简单相关分析及校正受教育程度后的偏相关分析显示MCI组脑脊液中P-tau水平与MMSE评分呈负相关(P<0.05)。结论:脑脊液中Aβ42和P-tau水平可能为MCI诊断提供依据。MCI患者中脑脊液P-tau水平可能与认知障碍的严重程度有关。Objective To investigate Aβ42 and P-tau levels in cerebrospinal fluid （CSF） of patients with mild cognitive impairment （MCI）. Methods CSF of 25 cases of MCI and 14 cases of cognitively normal （CN） were investigated. The CSF levels of Aβ42 and P-tau were detected by ELISA method. Correlation analysis was used to analyze the correlation between P-tau level and MMSE score in MCI. Results The CSF level of Aβ42 was higher and P-tau was lower in MCI than CN group（P 〈 0.05）. P-tau level in MCI was also negatively correlated with MMSE score （P 〈 0.05）. Conclusion Aβ42 and P-tau levels in CSF may be valuable biological markers in the diagnosis of MCI. P-tau level in CSF of MCI may be related to the severity of cognitive impairment.

关 键 词：认知障碍 β-淀粉样蛋白42 磷酸化TAU蛋白 脑脊液 

分 类 号：R749.1[医药卫生—神经病学与精神病学]