RhoA和C-myc在胃癌发生发展中的表达及意义  

The correlation between Rho A and C-myc expression and the development of gastric cancer

作　　者：王莉[1] 张旭[1] 刘丽秋[1] 孙玉鸿[1] 朱艳丽[1] 赵玉德[1] 江清林[2] 

机构地区：[1]佳木斯大学附属第一医院检验科,154003 [2]佳木斯大学基础医学院遗传学教研室,154007

出　　处：《实用医学杂志》2014年第19期3087-3089,共3页The Journal of Practical Medicine

基　　金：黑龙江省教育厅科学技术研究项目(编号:12531715)

摘　　要：目的:研究胃癌中Rho A及C-myc蛋白的表达及其其相关性,初步探讨它们在胃癌的侵袭转移中的生物学意义。方法:应用免疫组化SABC法,检测46例胃癌组织、20例正常胃黏膜组织中Rho A及Cmyc蛋白的表达情况,比较其与临床病理指标的关系及表达的相关性。结果:胃癌组织Rho A、C-myc表达的阳性率明显高于正常胃黏膜组织,组间比较差异有显著性(P<0.05);Rho A、C-myc表达水平与胃癌的分化程度、淋巴结转移、浸润深度有关(P<0.05);Rho A与C-myc具有相关性(r=0.62,P<0.05)。结论:提示Rho A与C-myc的表达与胃癌生物学行为密切相关;在胃癌发展过程中,两者可能共同作用,参与细胞的癌变过程,并促进癌变细胞的浸润、转移。Objective To study the expression of RhoA and C-myc in gastric carcinoma, and to discuss the action in infiltration and metastasis of gastric carcinoma as well as their dependability. Methods RhoA protein expression and C-myc protein expression were detected by immunohistochemical method in 46 cases of gastric carcinoma and 20 cases of normal tissues. RhoA protein expression was compared with clinical pathologic parameters as related to C-myc. Results The positive rate of RhoA, C-myc were significantly higher in gastric carcinoma than in normal tissue （P 〈 0.05）. The expression of RhoA and C-myc were associated with the loss of tumor differentiation, lymph node metastasis and deep invasion （P 〈 0.05）. There was a significant correlation between RhoA and C-myc （r = 0.62, P 〈 0.05 ）. Conclusions The data suggests that the expression level of RhoA protein was closely related to biological behavior of gastric carcinoma. RhoA and C-myc were possibly both correlated with the infiltration and metastasis of gastric carcinoma.

关 键 词：胃肿瘤 RHOA C-MYC 蛋白表达 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤]