依达拉奉治疗急性脑梗死患者的临床疗效及其对血清SOD、MDA水平的影响  

Clinical effect of edaravone on treatment of patients with acute cerebral infarction and its influence on serum SOD and MDA

作　　者：郑慧芬[1] 宗惠花[2] 俞燕[2] 赵彦平[2] 

机构地区：[1]南京医科大学附属脑科医院老年神经科,江苏南京210029 [2]江苏省宜兴市人民医院神经内科,江苏宜兴214200

出　　处：《实用临床医药杂志》2014年第17期18-21,共4页Journal of Clinical Medicine in Practice

基　　金：中国高校医学期刊临床专项资金(11321582)

摘　　要：目的观察依达拉奉治疗急性脑梗死患者的临床疗效及对血清超氧化物歧化酶(SOD)、丙二醛(MDA)的影响。方法选取64例急性脑梗死患者,随机分为治疗组33例,对照组31例。对照组给予基础药物治疗,治疗组在对照组的基础上给予依达拉奉,观察2组临床疗效、神经功能缺损改善总有效率及美国国立卫生研究院卒中量表(NIHSS)评分、日常生活能力Barthel指数量表评分,及血清SOD、MDA水平变化。结果治疗14 d后,治疗组总有效率为84.85%,对照组总有效率为61.29%,治疗组总有效率显著高于对照组(P<0.05)。治疗后2组患者的NIHSS、Barthel评分显著优于治疗前(P<0.01),组间比较有显著差异(P<0.05)。治疗后,治疗组的SOD水平显著高于治疗前(P<0.01),对照组患者的SOD水平显著低于治疗前(P<0.01),治疗组的MDA水平显著低于治疗前(P<0.01),对照组的MDA水平显著高于治疗前(P<0.05)。2组患者均无严重不良反应。结论在基础药物治疗上加用依达拉奉治疗急性脑梗死疗效确切安全。Obj ective To observe the clinical effect of edaravone on treatment of patients with acute cerebral infarction （ACI）and its influence on serum superoxide dismutase （SOD）and malondialdehyde （MDA）.Methods A total of 64 ACI patients were randomly divided into control group （31 cases）treated with basic medicines and treatment group （33 cases）added with with edar-avone.Clinical efficacy,neurological function deficit improvement rate,American National Insti-tutes of Health Stroke Scale （NIHSS）and Barthel index （BI）as well as serum SOD and MDA level changes in both groups were observed.Results 14 d after treatment,the clinical efficacy in treat-ment group was 84.85%,significantly higher than the 61.29% in control group （P＆lt;0.01）. NIHSS and Barthel scores were better after treatment than those before （P＆lt;0.01）,and differences between two groups were also significant （P＆lt;0 .05 ）.After treatment,SOD level was higher in treatment group （P＆lt;0 .0 1 ）and lower in control group than those before treatment （P＆lt;0 .0 1 ）, whereas MDA level was lower in treatment group （P＆lt;0 .0 1 ）and higher in control group than those before treatment （P＆lt;0 .05 ）.Additionally,there had no severe adverse responses in both groups. Conclusion On the basis of basic treatment,the application of edaravone has favorable clinical effi-cacy and safety in the treatment of ACI .

关 键 词：依达拉奉 脑梗死 自由基 血清超氧化物歧化酶 丙二醛 

分 类 号：R743[医药卫生—神经病学与精神病学]