Ki-67在弥漫大B细胞淋巴瘤中的表达及意义  

Clinical expression and significance of Ki-67 in diffuse large B cell lymphoma

作　　者：丛智荣[1] 刘红[2] 徐小红[1] 江棋[1] 沈茜[1] 曹永峰[1] 倪静怡[1] 

机构地区：[1]江苏省南通市肿瘤医院内科,江苏南通226361 [2]南通大学附属医院血液科,江苏南通226001

出　　处：《实用临床医药杂志》2014年第17期56-58,62,共4页Journal of Clinical Medicine in Practice

基　　金：中国高校医学期刊临床专项资金项目(11321386);江苏省医学创新团队与领军人才项目(LJ201136)

摘　　要：目的通过观察Ki-67在弥漫大B细胞淋巴瘤(DLBCL)与淋巴结反应性增生中以及在生发中心B细胞(GCB)型和非GCB型(non-GCB)中的表达差异,探讨Ki-67的临床意义。方法将60例DLBCL标本设为观察组,将20例淋巴结反应性增生组织标本设为对照组。比较Ki-67在GCB型和non-GCB型中的表达差异,并分析Ki-67与DLBCL分型、国际预后指数(IPI)、近期疗效、预后的关系。结果 Ki-67在观察组和对照组的平均表达率分别为(69.17±14.73)%和(40.50±1 4.95)%,差异有统计学意义(t=7.509,P<0.0001)。Ki-67在GCB型和non-GCB中的平均表达率分别为(59.29±14.92)%和(71.96±13.39)%,有显著差异(t=3.019,P=0.0038)。Ki-67在IPI<2组和IPI≥2组中的平均表达率分别为(65.29±15.17)%和(74.23±12.70)%,差别有统计学意义(t=2.422,P=0.0186)。结论 Ki-67的异常表达与DLBCL的临床分期、IPI指数、分型、近期疗效及预后等相关,对判断疗效和预后具有重要临床价值。Objective To investigate the different expressions of Ki-67 between diffuse large B cell lymphoma （DLBCL）and the reactive hyperplasia of lymphnode （RH）,germinal center B cells （GCB）and non-GCB types,and to explore the clinical significance of Ki-67.Methods Samples from 60 DLBCL patients served as observation group,while the other 20 tissue samples from patients with lymphoid reactive hyperplasia as control group.The difference of Ki-67 expres-sions between GCB and non-GCB were compared and the relationships between Ki-67 expression and DLBCL,the international prognostic index （IPI）,short-term efficacy and prognosis were analyzed. Results The average expression rate of Ki-67 was （69.17±14.73）%and （40.50±14.95）% in observation and control groups respectively ,and the difference was significant （t= 7 .5 0 9 ,P〈0.0001）,and it was （59.29±14.92）%and （71.96±13.39）%in GCB and non-GCB groups （t= 3.019,P= 0.0038）and （65.29±15.17）% and （74.23±12.70）% in IPI〈2 and IPI≥2 groups （t= 2.422,P= 0.0186）,respectively.Conclusion The abnormal expression of Ki-67 is closely associated with clinical stages,index of IPI,types,short-term effect and prognosis in DLB-CL,which plays an important role in the diagnosis,treatment and prognosis of DLBCL.

关 键 词：KI-67 弥漫大B细胞淋巴瘤 预后 

分 类 号：R733[医药卫生—肿瘤]