A lignin glycoside and a nortriterpenoid from Kadsura coccinea  

作　　者：YEON Jae-Ho CHENG Liang HE Quan-Quan KONG Ling-Yi 

机构地区：[1]State Key Laboratory of Natural Medicines,Department of Natural Medicinal Chemistry,China Pharmaceutical University [2]Amorepacific Shanghai R & I Center [3]State Key Laboratory of New Drug and Pharmaceutical Process,Shanghai Institute of Pharmaceutical Industry,China State Institute of Pharmaceutical Industry

出　　处：《Chinese Journal of Natural Medicines》2014年第10期782-785,共4页中国天然药物（英文版）

基　　金：supported by the Program for New Century Excellent Talents in University(NCET-12-0977);the National New Drug Innovation Great Project of China(2011ZX09307-002-02);the Program for Changjiang Scholars and Innovative Research Team in a University(PCSIRT-IRT1193);the Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)

摘　　要：AIM: To study the chemical constituents of the roots and stem bark of Kadsura coccinea. METHOD: Compounds were isolated by column chromatography on silica gel and Sephadex LH-20, and finally purified by prep-HPLC. Their structures were elucidated by extensive spectroscopic methods, including 1D- and 2D-NMR, and HR-ESI-MS. RESULTS: Two compounds were determined as(7′S,8′S,8R)-(8β,8′α)- dimethyl-4,4′-dihydroxy-5,3′-dimethoxy-5′-cyclolignan glucoside(1) and micrandiactone H(2), respectively. CONCLUSION: Compunds 1 and 2 are new and neither showed inhibitory effects on nitric oxide(NO) production in lipopolysaccharide-induced RAW264.7 macrophages.AIM： To study the chemical constituents of the roots and stem bark of Kadsura coccinea. METHOD： Compounds were isolated by column chromatography on silica gel and Sephadex LH-20, and finally purified by prep-HPLC. Their structures were elucidated by extensive spectroscopic methods, including 1D- and 2D-NMR, and HR-ESI-MS. RESULTS： Two compounds were determined as（7′S,8′S,8R）-（8β,8′α）- dimethyl-4,4′-dihydroxy-5,3′-dimethoxy-5′-cyclolignan glucoside（1） and micrandiactone H（2）, respectively. CONCLUSION： Compunds 1 and 2 are new and neither showed inhibitory effects on nitric oxide（NO） production in lipopolysaccharide-induced RAW264.7 macrophages.

关 键 词：Kadsura coccinea SCHISANDRACEAE Lignan glucoside TRITERPENOID 

分 类 号：R284.1[医药卫生—中药学]