经直肠超声造影与经直肠常规超声诊断前列腺癌的比较研究  

Comparative study between transrectal contrast-enhanced ultrasound and routine transrectal ultrasound in the diagnosis of prostate cancer

作　　者：张帆[1] 汪维[1] 黄海锋[1] 常小峰[1] 郭宏骞[1] 

机构地区：[1]南京大学医学院附属鼓楼医院泌尿外科,南京210008

出　　处：《临床泌尿外科杂志》2014年第9期757-760,共4页Journal of Clinical Urology

摘　　要：目的：比较经直肠超声造影与经直肠常规超声诊断前列腺癌的各自优势。方法：选择前列腺癌患者213例,年龄54~83岁,平均71岁。检测PSA为4.12~150.00μg/L,平均22.53μg/L。先行经直肠常规超声检查,再行经直肠前列腺超声造影检查,绘制时间强度曲线（TIC曲线）,分别判读常规超声和超声造影结果。随后行12针前列腺系统穿刺活检。结果：213例患者中,常规超声诊断前列腺癌123例,超声造影诊断前列腺癌113例,穿刺活检病理确诊前列腺癌99例。常规超声与病理检查的诊断符合率为53.52%,超声造影与病理检查的诊断符合率为80.28%。两种诊断方法敏感度、特异度、假阳性率、假阴性率、漏诊率、病理检查符合率差异均有统计学意义（P〈0.05）。结论：经直肠超声造影可灵敏显示前列腺血流分布情况,对前列腺癌的诊断有较高的准确性,值得推广使用。Objective： To evaluate the advantages of transrectal contrast-enhanced ultrasound compared with routine transrectal ultrasound in the diagnosis of prostate cancer. Method： We selected 213 cases with prostate cancer whose mean age was 71 （range, 54-83） years. Their PSAs were from 4.12 to 150 （average, 22.53） μg/L. All patients were examined by routine transrectal ultrasound and transrectal contrast-enhanced ultrasound, and the time-intensity curve （TIC） was drawn. Then, the diagnoses of routine ultrasound and contrast-enhanced ultra- sound were made. Subsequently, 12-core systemic prostate biopsy was taken. Result：All 213 patients, 123 cases were diagnosed with prostate cancers by routine ultrasound, 113 cases were diagnosed with prostate cancers by contrast-enhanced ultrasound, and 99 cases were diagnosed with prostate cancers by pathology. The coincidence rate of routine ultrasound and pathology was 53.52%, and the coincidence rate of contrast-enhanced ultrasound and pathology was 80. 28%. P values of the sensitivities, specificities, false positive rates, false negative rates, rates of misdiagnosis, pathological coincidence rates between transrectal contrast-enhanced ultrasound and routine transrectal ultrasound were less than 0.05, which meant there were significant differences. Conclusion：Transrectal contrast-enhanced ultrasound can show the distribution of blood flow in prostate sensitively. It is worth promoting for it can diagnose prostate cancer accurately.

关 键 词：前列腺癌 常规超声 超声造影 前列腺穿刺活检 

分 类 号：R737.25[医药卫生—肿瘤]