细胞因子信号传导抑制蛋白-3在前列腺癌中作用的研究进展  

Research progress of suppressor of cytokine signaling-3in prostate cancer

作　　者：李晟[1] 王大文[1] 朱诗建 木海琦[1] 杨森[1] 南存金[1] 张磊[1] 陈映鹤[1] 

机构地区：[1]温州医科大学附属第二医院泌尿外科,浙江温州325027

出　　处：《临床泌尿外科杂志》2014年第9期845-847,共3页Journal of Clinical Urology

摘　　要：细胞因子信号抑制蛋白-3(suppressor of cytokine signaling-3,SOCS-3)是一种很常见的抑制性信号调节蛋白,可参与负反馈调节Janus激酶、转录激活因子(JAK/STAT)及信号转导等多种重要信号通路,从而调控细胞因子、生长因子等对细胞的作用。SOCS-3可通过多种机制调节前列腺癌细胞的迁移及侵袭能力。本文主要就SOCS-3在这一方面的研究进展作一简单综述。The suppressor of cytokine signaling-3 （SOCS-3） is a common inhibitory signal regulatory protein. It can participate in the negative feedback regulation of Janus kinase/signal transducer and activator of transcrip- tion （JAK/STAT） and other important signaling pathways, so as to regulate role of cytokines and growth factors on cells. Migration and invasion ability of prostate cancer cells can be regulated by SOCS-3 through a variety of mechanisms. This paper will provide a brief review on it.

关 键 词：前列腺癌 细胞因子信号传导抑制蛋白-3 肿瘤侵袭与转移 

分 类 号：R737.25[医药卫生—肿瘤]