Cancer immunotherapy in clinical practice—the past,present,and future  

作　　者：Gaurav Goel Weijing Sun 

机构地区：[1]Division of Hematology-Oncology,Department of Medicine,University of Pittsburgh Cancer Institute [2]University of Pittsburgh School of Medicine

出　　处：《Chinese Journal of Cancer》2014年第9期445-457,共13页

摘　　要：Considerable progress has been made in the field of cancer immunotherapy in recent years. This has been made possible in large part by the identification of new immune-based cellular targets and the development of novel approaches aimed at stimulating the immune system. The role played by the immunosuppressive microenvironment in the development of tumors has been established. The success of checkpoint-inhibiting antibodies and cancer vaccines has marked the beginning of a new era in cancer treatment. This review highlights the clinically relevant principles of cancer immunology and various immunotherapeutic approaches that have either already entered mainstream oncologic practice or are currently in the process of being evaluated in clinical trials. Furthermore, the current barriers to the development of effective immunotherapies and the potential strategies of overcoming them are also discussed.Considerable progress has been made in the field of cancer immunotherapy in recent years. This has been made possible in large part by the identification of new immune-based cellular targets and the development of novel approaches aimed at stimulating the immune system. The role played by the immunosuppressive microenvironment in the development of tumors has been established. The success of checkpoint-inhibiting antibodies and cancer vaccines has marked the beginning of a new era in cancer treatment. This review highlights the clinically relevant principles of cancer immunology and various immunotherapeutic approaches that have either already entered mainstream oncologic practice or are currently in the process of being evaluated in clinical trials. Furthermore, the current barriers to the development of effective immunotherapies and the potential strategies of overcoming them are also discussed.

关 键 词：癌症治疗 免疫疗法 临床实践 免疫治疗 免疫系统 临床试验 肿瘤学 微环境 

分 类 号：R730.51[医药卫生—肿瘤]