Genetics of obstructive sleep apnea/hypopnea syndrome  

作　　者：Zhang Dongmei Xiao Yi Luo Jinmei 

机构地区：[1]Department of Internal Medicine,Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academyof Medical Sciences, Beijing 100730, China [2]Department of Respiratory Medicine,Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academyof Medical Sciences, Beijing 100730, China

出　　处：《Chinese Medical Journal》2014年第17期3135-3141,共7页中华医学杂志（英文版）

摘　　要：Objective To have a better understanding of genetic contributions to the development of obstructive sleep apnea hypopnea syndrome （OSAHS） by reviewing studies on its genetic basis.Data sources A comprehensive search of the PubMed literature without restriction on the publication date was carried out using terms ＂obstructive sleep apnea＂ and ＂candidate genes＂ or ＂genetics＂.Study selection Articles were selected if they were an original research paper or meta analysis of the genetic factors of OSAHS.Results Four intermediate phenotypes were described and several candidate genes that may determine the expression and severity of OSAHS were reviewed.Conclusion Multiple gene-gene interactions occurring in genes that affect obesity,craniofacial structure,ventilator control and asleep-awake pattern may influence the expression of OSAHS in a suitable environment.Objective To have a better understanding of genetic contributions to the development of obstructive sleep apnea hypopnea syndrome （OSAHS） by reviewing studies on its genetic basis.Data sources A comprehensive search of the PubMed literature without restriction on the publication date was carried out using terms ＂obstructive sleep apnea＂ and ＂candidate genes＂ or ＂genetics＂.Study selection Articles were selected if they were an original research paper or meta analysis of the genetic factors of OSAHS.Results Four intermediate phenotypes were described and several candidate genes that may determine the expression and severity of OSAHS were reviewed.Conclusion Multiple gene-gene interactions occurring in genes that affect obesity,craniofacial structure,ventilator control and asleep-awake pattern may influence the expression of OSAHS in a suitable environment.

关 键 词：sleep apnea  obstructive GENETICS PHENOTYPE 

分 类 号：R766[医药卫生—耳鼻咽喉科]