脑深部电刺激治疗难治性癫  

Treatment of intractable epilepsy by deep brain stimulation

作　　者：鲍民[1] 周健[1] 赵萌[1] 任杰[1] 张尧[1] 栾国明[1] 

机构地区：[1]北京三博脑科医院(首都医科大学第十一临床医学院)功能神经外科,100093

出　　处：《中国微侵袭神经外科杂志》2014年第9期395-397,共3页Chinese Journal of Minimally Invasive Neurosurgery

基　　金：卫生部重点专科建设项目(编号:SG2011-02-1-5);首都医科大学基础-临床合作基金(编号:13JL89)

摘　　要：目的探讨脑深部电刺激（deep brain stimulation,DBS）在治疗难治性癫中的应用。方法回顾性分析接受DBS治疗的4例难治性癫病人的临床资料,1例选择丘脑前核电刺激,3例选择杏仁核-海马复合体电刺激。分析DBS治疗难治性癫的术前评估、手术方法及治疗效果。结果随访11-33个月,3例病人发作均减少50%以上,1例无效。结论对于不适合接受开颅切除性手术治疗的药物难治性癫病人,DBS治疗为安全而有效地治疗方式之一。靶点的选择主要依据癫癎样放电的部位及特点。Objective To investigate the application of deep brain stimulation （DBS） for intractable epilepsy. Methods Clinical data of 4 intractable epilepsy patients undergoing DBS were analyzed retrospectively. The stimulation targets were anterior nucleus of the thalamus （ANT） in 1 patient and amygdala-hippocampus complex （AH-C） in 3 patients. The preoperative evaluation, surgical techniques and outcome of DBS in the treatment of intractable epilepsy were analyzed. Results All the patients were followed-up for 11 to 33 months, seizures were reduced by more than 50% in 3 patients and invalid in 1. Conclusions For patients with intractable epilepsy who are not suitable for craniotomy surgery for resection, DBS is a safe,and effective treatment. Target choice is based mainly on the site and characteristics of epileptiform discharges.

关 键 词：癫癎 难治性 脑深部电刺激 丘脑前核 杏仁核-海马复合体 

分 类 号：R742.1[医药卫生—神经病学与精神病学]