胃癌组织中SNCG和CXCR4 mRNA的表达及临床意义  

Expression of SNCG and CXCR4 mRNAs in gastric adenocarcinoma and its clinical significance

作　　者：郑淑芳[1] 时丽芳[1] 于健[2] 

机构地区：[1]武警后勤学院附属医院病理科,天津市300162 [2]武警后勤学院附属医院普外科,天津市300162

出　　处：《中国肿瘤临床》2014年第17期1094-1097,共4页Chinese Journal of Clinical Oncology

基　　金：天津市应用基础及前沿技术研究计划面上项目(编号:11JCYBJC13000);武警后勤学院附属医院种子基金项目(编号:FYM201216);武警后勤学院面上项目(编号:WYM201009)资助~~

摘　　要：目的:研究SNCG和CXCR4在胃癌和正常胃黏膜组织中的表达,探讨其在胃癌发生、发展、浸润转移中的作用。方法:应用RT-PCR法检测不同组织中SNCG和CXCR4 mRNA的表达情况。结果:SNCG和CXCR4 mRNA在胃癌组织中的表达量明显高于正常胃黏膜组织(P<0.01);胃癌组织中SNCG mRNA的表达量与癌组织的浸润深度和淋巴结转移有关(P<0.05,P<0.01),CXCR4mRNA的表达量与淋巴结转移有关(P<0.01);胃癌组织中SNCG mRNA与CXCR4 mRNA的表达量呈正相关(r=0.346,P<0.05)。结论:SNCG和CXCR4在胃癌组织中高表达,可能与胃癌的发生、发展、浸润、转移密切相关。Objective：To detect expression of SNCG and CXCR4 mRNA in gastric adenocarcinoma and evaluate its function in carcinogenesis, progression, infiltration, and metastasis, as well as the correlation of these proteins. Methods：The expression of SNCG and CXCR4 mRNAs was detected using reverse transcription-polymerase chain reaction in gastric adenocarcinoma and normal gastric mucosa. Results：The expression of SNCG and CXCR4 mRNAs was obviously higher in gastric adenocarcinoma than in normal gastric mucosa （P〈0.01）. The expression of SNCG mRNA was closely correlated with tumor infiltration depth （P〈0.05） and lymph node metas-tasis （P〈0.01）. The expression of CXCR4 mRNA closely correlated with lymph node metastasis （P〈0.01）. The expression of SNCG and CXCR4 mRNAs positively correlated in 29 cases of gastric adenocarcinoma （r=0.346, P〈0.05）. Conclusion：SNCG and CXCR4 may be overexpressed in tumor tissue and may have important functions in tumorigenesis, progression, infiltration, and metastasis of gastric adenocarcinoma.

关 键 词：SNCG CXCR4胃癌浸润转移 

分 类 号：R735.2[医药卫生—肿瘤]