超声弹性成像评分对鉴别乳腺肿瘤良恶性的价值  

Correlation between ultrasound elastography and ER/PR and its value in differentiating between malignant and benign solid breast masses

作　　者：梁喜[1] 刘俊[1] 王云芙[1] 王巧云[1] 

机构地区：[1]无锡市妇幼保健院超声科,江苏214002

出　　处：《放射学实践》2014年第9期1092-1095,共4页Radiologic Practice

基　　金：江苏省科技资助项目(50305030284)

摘　　要：目的:分析弹性成像评分与免疫组织化学因子雌激素受体(ER)、孕激素受体(PR)的关系,探讨弹性成像评分对鉴别乳腺肿瘤良恶性的价值。方法:选取乳腺肿瘤患者100例,运用彩色超声弹性成像技术对患者的病灶进行探查,采用免疫组织化学技术对患者新鲜活检组织标本进行处理,记录其ER和PR值,并进行统计学分析。结果:乳腺肿瘤弹性成像评分与ER(rs=0.835,P=0.000)及PR(rs=0.816,P=0.000)的表达程度均呈正相关。超声弹性成像评分诊断乳腺肿瘤良恶性的总体符合率达到73%,与免疫组织化学方法近似(ER:71%,PR:61%),差异不具有统计学意义(P>0.05)。结论:乳腺弹性成像评分与病灶ER及PR蛋白表达呈正相关,对鉴别乳腺肿瘤良恶性具有重要价值。To analyze the correlation between ultrasound elastography and immunohistochemical factors-estrogen receptor （ER）and progestin receptor （PR）,and to explore the value of elastography score in differentiating be-tween malignant and benign solid breast masses.Methods：A total of 100 patients with breast masses were involved in the study at our hospital.Elastography was used to assess breast masses,while fresh biopsy specimens were treated with immu-nohistochemistry technology and their ER and PR were recorded.Results：The breast elastography scores were positively correlated with the expression of ER （rs=0.835,P=0.000）and PR （rs=0.816,P=0.000）.The overall coincidence rate achieved by elastography was 73%,which was similar to the overall coincidence rate achieved by immunohistochemistry de-tection （ER 71%,PR 61%）.The difference presented no statistical significance （P〉0.05）.Conclusions：The breast elastog-raphy scores were positively correlated with the protein expression of ER and PR.The findings are significant for differenti-ating between malignant and benign solid breast masses.

关 键 词：乳腺肿瘤 弹性成像技术 雌激素受体 孕激素受体 

分 类 号：R737.9[医药卫生—肿瘤] R445.1[医药卫生—临床医学]