检测Cys C、血浆u Ⅱ浓度对亚临床失代偿肝硬化合并HRS患者的临床意义  

Diagnostic value of plasma cystitis C and pretension Ⅱ inpatients with decompensated cirrhosis and hepatorenal syndrome

作　　者：杨科[1] 杨启[1] 

机构地区：[1]河南省南阳市中心医院肝脏普外科,河南省南阳市473000

出　　处：《世界华人消化杂志》2014年第23期3495-3498,共4页World Chinese Journal of Digestology

摘　　要：目的:对在失代偿期肝硬化合并肝肾综合征(hepatorenal syndrome,HRS)患者进行诊断时血浆尾加压素Ⅱ(pretensionⅡ,uⅡ)以及胱抑素C(cystitis C,CysC)的诊断价值进行探讨.方法:选择2012-03/2013-12南阳市中心医院收治的失代偿期肝硬化患者100例作为研究对象,同时还选取30例健康体检者作为对照组,对患者的各项指标进行检测,对上述各组各指标的差异进行比较.结果:两组患者在血浆uⅡ、CysC、血清肌酐、白蛋白(albumin,Alb)、总胆汁酸(total bile acids,TBA)、谷草转氨酶(aspartatetransaminase,AST)以及谷丙转氨酶(alanineaminotransferase,ALT)等各项指标比较差异显著具有统计学意义(t=12.8285,6.587417.5857,12.9540,6.0944,4.5689,4.4468P<0.05).在TBA、Alb、AST、ALT等各项指标上,HRS组、亚临床HRS组以及单纯肝硬化组之间差异无统计学意义(P>0.05).在亚临床HRS组以及单纯肝硬化组之间Scr浓度差异无统计学意义(P>0.05),在亚临床HRS组与HRS组之间Scr浓度差异显著具有统计学意义(P<0.05).结论:血浆uⅡ以及CysC的浓度对于亚临床失代偿期肝硬化合并HRS的早期发现具有十分重要的作用.AIM： To assess the diagnostic value of plasma pretension Ⅱ（uⅡ） and cystitis C（CysC） in pa-tients with hepatorenal syndrome（HRS） and decompensated cirrhosis.METHODS： One hundred patients with decom-pensated cirrhosis treated at our hospital from March 2012 to December 2013 were included.Thirty healthy volunteers were used as controls.Plasma and serum indicators were detected and compared between the two groups.RESULTS： The two groups of patients differed significantly with respect to plasma uⅡ,CysC,serum creatinine,albumin（Alb）,total bile acids（TBA）,aspartame aminotransferase（AST） and almandine aminotransferase（ALT）（t = 12.8285,6.5874,17.5857,12.9540,6.0944,4.5689,4.4468,P〈0.05）.TBA,Alb,AST and ALT did not differ significantly between the HRS group,subclinical HRS group and simple cirrhosis（P〈0.05）.Al-though Scr concentration differed significantly between the HRS group and subclinical HRS group（P〈0.05）,it was not significantly dif-ferent between the subclinical HRS group and simple cirrhosis group（P〈0.05）.CONCLUSION： Detection of plasma uⅡ and CysC is helpful for the early detection of HRS in patients with decompensated cirrhosis.

关 键 词：血浆尾加压素Ⅱ 胱抑素C 肝肾综合征 

分 类 号：R575.2[医药卫生—消化系统] R692[医药卫生—内科学]