舍曲林联合奥替溴铵治疗肠易激综合征患者30例  

Clinical efficacy of sertralinecombined with otilonium bromide in irritable bowel syndrome patients

作　　者：王亚军[1] 

机构地区：[1]海安县中医院消化内科,江苏省海安县226600

出　　处：《世界华人消化杂志》2014年第23期3517-3520,共4页World Chinese Journal of Digestology

摘　　要：目的:探究舍曲林联合奥替溴铵治疗肠易激综合征(irritable bowel syndrome,IBS)的临床疗效.方法:选取2010-01/2012-10于海安县中医院就诊的IBS患者60例,依据分层随机分组方法将患者分为治疗组与对照组,每组30例.对照组仅给予口服奥替溴铵(40 mg/次,3次/d),治疗组予以口服舍曲林(50 mg/次,1次/d)联合口服奥替溴铵(40 mg/次,3次/d).两组均治疗4 wk.观察两组患者治疗前及治疗4 wk后腹痛评分、焦虑自评量表(self-rating anxiety scale,SAS)评分、抑郁自评量表(self-rating depression scale,SDS)评分及治疗效果,同时观察两组患者药物不良反应的发生情况.结果:治疗前两组患者指标均未见明显差异(P>0.05),治疗4 wk后,治疗组患者的腹痛评分(0.72分±0.23分)、SAS评分(36.57分±5.44分)及SDS评分(34.15分±5.84分)均明显低于对照组患者的腹痛评分(1.37分±0.29分)、SAS评分(42.91分±6.48分)及SDS评分(42.05分±8.17分),而且治疗组患者的总有效率86.67%明显高于对照组的的总有效率60.00%(P<0.05).同时,治疗组患者的药物不良反应发生情况两组间比较差异无统计学意义(P>0.05).结论:相比于仅采用奥替溴铵来治疗IBS,应用舍曲林联合奥替溴铵治疗能更好地改善患者的腹痛及精神焦虑、抑郁等不良情绪以及提高治疗的总体效果,值得临床推广使用.AIM： To assess the clinical efficacy of sertralinecombined with otilonium bromide in irritablebowel syndrome（IBS） patients.METHODS： Sixty IBS patients treated at ourhospital from January 2010 to October 2012 were included.The patients were randomlydivided into either a treatment group or a con-trol group,with 30 patients in each group.Thetreatment group was orally administered withotilonium bromide（40 mg/time,3 times/d）combined with sertraline（50 mg/time,1 time/d）.The control group was given otiloniumbromide（40 mg/time,3 times/d） alone.Thetreatment lasted 4 wk in both group.Abdomi-nal pain score,self-rating anxiety scale（SAS）score,self-rating depression scale（SDS） scoreand clinical efficacy before and 4 weeks afterthe therapy were compared between the twogroups.Adverse reactions of drugs were alsorecorded.RESULTS： The indexes showed no significant differences before treatment between the two groups（P〈0.05）.After 4 wk of the treatment,abdominal pain score（0.72 points ± 0.23 points vs 1.37 points ± 0.29 points）,SAS score（36.57 points ± 5.44 points vs 42.91 points ± 6.48 points）,and SDS score（34.15 points ± 5.84 points vs 42.05 points ± 8.17 points） were all significantly lower in the treatment group than in the control group（P〈0.05）.The response rate was signifi-cantly higher in the treatment group than in the control group（86.67% vs 60.00%,P〈0.05）.The incidence of adverse drug reactions was not sta-tistically significant between the two groups（P〈0.05）.CONCLUSION： Compared to the otilonium bro-mide alone,sertraline combined with otilonium bromide is better in the remission of abdominal pain and negative emotions like mental anxiety and depression,and can improve the overall ef-fectiveness.

关 键 词：舍曲林 奥替溴铵 肠易激综合征 腹泻 抑郁 

分 类 号：R574.4[医药卫生—消化系统]