介入化疗栓塞联合体部γ刀治疗原发性肝癌83例疗效观察  

TRANSCATHETERARTERIAL CHEMOEMBOLIZATION COMBINED WITH LOCALγ- KMIFE IN TREATMENT OF PRIMARY LIVER CANCER

作　　者：周士琦[1] 杨德久[1] 张军舰[1] 刘金伟[1] 张慧英[1] 赵志宇[1] 白静[1] 郭兰[1] 韩淑英[1] 

机构地区：[1]河北联合大学附属医院,河北省唐山市063000

出　　处：《中国煤炭工业医学杂志》2014年第9期1387-1390,共4页Chinese Journal of Coal Industry Medicine

基　　金：河北省唐山市科技局指令性课题(编号:12140209A-64)

摘　　要：目的探讨肝动脉介入化疗栓塞（TACE）联合体部7刀治疗原发性肝癌的治疗效果。方法选择2006年10月～2011年10月收治的原发性肝癌患者195例。83例行肝动脉介入化疗栓塞联合体部γ刀治疗（立体定向放射治疗）；112例单纯行体部γ刀治疗；二组处方等剂量线均采用50％～65％等剂量包绕计划靶区；靶周单次剂量2．8～4Gy／次，治疗次数为8～12次，总靶周放射剂量33．6～44Gy。结果治疗后3个月观察组总有效率为90．3％，对照组总有效率为73．2％，二组总有效率比较差异有统计学意义（P〈0．05）；对照组患者的1、2、5年生存率分别为66．9％、47．3％，18．0％，平均生存为（18．1±2．5）个月。观察组患者的1、2、5年生存率分别为48．1％、32．5％，3．6％，平均生存期为（15．6±2．3）个月。二组生存率及平均生存期比较差异有统计学意义（P〈0．05）。随访期内未见严重放射性并发症。结论体部γ刀配合介入化疗栓塞治疗原发性肝癌，操作简单，无创伤，副作用较轻，并发症少。能起到一个很好的协同作用，并且效果明显，值得推荐。Objective To evaluate the efficacy of transcatheterarterial chemoembolization （TACE） combined with local γ- knife in treatment of primary liver cancer. Methods Of the 195 patients with primary liver cancer from the October 2006 to October 2011, 83 cases who received transcatheterarterial chemoembolization （TACE） combined with local γ-knife （stereotactic radiotherapy ） were selected as case group; 112 cases who only received local γ- knife were selected as control group; 50% - 65% isodose line was administered surrounding the planning target area in two groups; the single radiation dose was 2. 8 Gy- 4 Gy/time , the number of the treatment were 8 to 12, the total radiation dose was 33.6 Gy- 44 Gy. Results 3 months after treatment, the total effective rate was 90.3% in the case group and 73.2% in the control group, there was statistics significance between the two groups （ P〈0.05） ; The 1 - , 2 - , 5 - year survival rates of patients in case group were 66.9%, 47.3%, 18.0% respectively, the average survival time was（18.1 ± 2.5） months, median survival time was 25.6 months. The 1 - , 2 - , 5 - year survival rates of patients in case group were 48.1%, 32.5%, 3.6% respectively, the average survival time was （15.1 ± 2.3） months, median survival time was 22.3 months. There was statistical difference between the two groups in survival rate and survival time （P〈0.05）. There was no serious complications during the follow - up period. Conclusions For the treatment of primary liver cancer, the curative effect who treated with transcatheterarterial chemoembolization combined with local γ- knife is better than the patients who treated only with local γ- knife.

关 键 词：原发性肝癌 肝动脉 介入化疗 栓塞治疗 体部Γ刀 

分 类 号：R735.7[医药卫生—肿瘤]