铜催化一锅法合成吡咯[1,2-a]喹喔啉衍生物  

One-Pot Synthesis of Pyrrolo[1,2-a]quinoxaline Derivatives through Copper-Catalyzed Cascade Reactions

作　　者：蒋增强[1] 张杰[1] 童耀 史雪松[1] 苗大状 韩世清[1] 

机构地区：[1]南京工业大学生物与制药工程学院,南京211816

出　　处：《有机化学》2014年第9期1845-1850,共6页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.21072095);江苏省研究生创新工程(No.CXLX13_433)资助项目~~

摘　　要：建立了一种简单实用、经济高效的以邻碘苯胺、吡咯甲醛为起始原料,廉价的CuI为催化剂,价廉、易获得的2,2-联吡啶为配体,110℃条件下一锅法合成吡咯[1,2-a]喹喔啉类衍生物的催化体系,得到中等到优良产率.本方法具有催化剂廉价易得、操作简便、合成效率高的优点.A simple, efficient, inexpensive one-pot method for the pyrrolo[1,2-a]quinoxaline derivatives synthesized from 2-formylazoles and o-aminoiodoarenes was developed by using cheap CuI as catalyst, inexpensive and readily available 2,2＇-bipyridine as ligand at 110 ℃. The reaction provides an efficient protocol to a series of pyrrolo[ 1,2-a]quinoxaline deriva- tives in good to high yields, and benefits of readily available catalyst and synthesis of high efficiency.

关 键 词：一锅法合成 吡咯[1 2-a]喹喔啉 铜催化 

分 类 号：O626.13[理学—有机化学]