依达拉奉对高血压脑出血急性期患者C-反应蛋白的影响  

The Effect of Edaravone on C-reactive Protein of the Patients with Hypertensive Cerebral Hemorrhage at Acute Stage

作　　者：陈明生[1] 唐毅[1] 缪学建[1] 羊飞龙[1] 杨福兵[1] 

机构地区：[1]泸州医学院附属医院神经外科,四川泸州646000

出　　处：《西南军医》2014年第5期492-494,共3页Journal of Military Surgeon in Southwest China

摘　　要：目的探讨依达拉奉对高血压脑出血急性期患者C-反应蛋白的影响及作用机理。方法选取180例高血压脑出血急性期患者随机分为治疗组与对照组各90例,每组再根据病情程度分为轻、中、重三型,两组均予以常规治疗,治疗组则加用依达拉奉。分别于第1、4、7、10、14d检测两组患者血清CRP浓度,同型之间比较差异,分别于第1d和第14d对患者进行神经功能缺损评分并比较其差异。结果两组患者入院血清CRP均高于正常,第4d达高峰,并且与病情严重程度成正相关,第7d开始逐渐下降,治疗4、7、10、14d治疗组各型血清CRP水平均低于相应对照组(P<0.05),治疗组重型水平下降明显,治疗后第14d治疗组各型神经功能缺损评分均低于相应对照组(P<0.05)。结论依达拉奉能降低急性高血压脑出血患者血清CRP水平,能促进高血压脑出血患者临床症状改善。Objective To explore the effect of edaravone on of the patients with hypertensive cerebral hemorrhage at acute stage and the mechanism. Methods 180 patients were randomly divided into 2 groups：treatment group and control group, 90 in each;each group was further divided into 3 subgroups：slight subgroup, moderate group and severe group;routine treatment was given to all the pa-tients in the 2 groups while edaravone was added to patients in treatment group;the concentration of serum CPR was detected on the 1st day, the 4th day, the 7th day, the 10th day and the 14th day of the treatment and a comparative study was made among the subgroups;the neurological deficit scores were measured on the 1st day and the 14th day of the treatment and the difference among the groups were stud-ied. Results The levels of serum CPR of all the patients at admission were higher than normal and reached the peak on the 4th day of the treatment, there existed a positive correlation with the severity of disease, they started decreasing from the 7th day of the treatment;the levels of the patients in each subgroup of treatment group were lower than those of the patients in subgroups of control group on the 7th day, the 10th day and the 14th day of the treatment （P〈0.05）, the decrease in severe subgroup of treatment group was most obvious;the neurological deficit scores of patients in each subgroup of treatment group were lower than those of patients in each subgroup of control group on the 14th day of the treatment （P〈0.05）. Conclusions Edaravone is effective in decrease the level of serum CPR of the patients with acute hypertensive cerebral hemorrhage and promote the improvement of clinical symptoms.

关 键 词：高血压脑出血 C-反应蛋白 依达拉奉 

分 类 号：R743.2[医药卫生—神经病学与精神病学]