不同树脂对埃博霉素的吸附研究  

Studies on the adsorption of epothione by different resins

作　　者：李灿[1] 赵林[1] 刘新利[1] 

机构地区：[1]齐鲁工业大学山东省微生物工程重点实验室,山东济南250353

出　　处：《齐鲁工业大学学报》2014年第2期1-5,共5页Journal of Qilu University of Technology

基　　金：省级博士后创新基金会(201203006);山东省科技支撑计划项目(2012GSF12107)

摘　　要：本实验从降低成本的角度出发,利用从市场上购置的30种不同的国产树脂,从中选出两种吸附效果好的混合树脂:大孔吸附树脂XD-5与强碱性阴离子交换树脂D202以7∶3混合使用,可以使纤维堆囊菌So2161的埃博霉素A和B的产量较单一的大孔吸附树脂XAD-16分别提高252%和262%。进一步的研究结果表明,大孔吸附树脂XD-5对纤维堆囊菌发酵过程中的杂质吸附能力较XAD-16弱,从而能更好的吸附埃博霉素;强碱性阴离子交换树脂D202可以显著促进纤维堆囊菌的生长,进而提高了埃博霉素的产量。From the perspective of reducing production cost of epothilones,the effect of 30 different resins on epothilones yield of Sorangium cellulosum So2161 was surveyed. The mix of different advantageous resins has better effect on epothilone yield than single one. Exclusively,the mix of resin XD-5and D202with the ratio of 7 to 3 could improve yields of epothilone A and B by 252% and 262% respectively. As the adsorption of impurities,the capacity of macroporous adsorption resin XD-5 is inferior to the resin XAD-16,strongly basic anion exchange resin D202 can promote the growth of Sorangium cellulosum,because of which,the productivity of epothilone could be increased.

关 键 词：纤维堆囊菌 树脂 埃博霉素 

分 类 号：R979.1[医药卫生—药品]