巴格列酮的合成新方法  

A Novel Method to Synthesizing Balaglitazone

作　　者：刘昭文[1] 杨凯[1] 陈治希[1] 李洪亮[1] 余磊[1] 程齐来[1] 

机构地区：[1]赣南医学院,江西赣州341000

出　　处：《广州化学》2014年第3期48-51,共4页Guangzhou Chemistry

摘　　要：以4-羟基苯甲醛和2,4-噻唑烷二酮为起始原料,经Knoevenagel反应、催化氢化、醚化共三步反应得到目标物巴格列酮,总收率为76.1%。产物结构经MS、1H-NMR等确证。该方法原料易得,反应条件温和,危险性小,后处理简单,收率较高,生产成本降低,有利于工业化大生产。Using 4-Hydroxy-benzaldehyde and thiazolidine-2,4-dione as raw martial, balaglitazone was synthesized by Knoevenagel reaction, catalytic hydrogenation and etherification with the total yield of 76.1%. The structure of the target product was verified by MS and 1H-NMR spectra. This synthetic route with lower cost and mild reaction conditions and high yield which was worthy to have a further pilot manufacture.

关 键 词：4-羟基苯甲醛 KNOEVENAGEL反应 巴格列酮 

分 类 号：O636.11[理学—高分子化学]