川芎清脑颗粒治疗偏头痛的疗效观察  

Efficacy Observation of Chuanxiong Qingnao Granules in the Treatment of Migraine

作　　者：白蓉[1] 史银玲[1] 

机构地区：[1]郑州大学第一附属医院神经内科

出　　处：《中国药房》2014年第39期3708-3710,共3页China Pharmacy

摘　　要：目的:观察川芎清脑颗粒治疗偏头痛的临床效果。方法:收集我院2013年4-11月偏头痛患者59例,按随机数字表法分为治疗组29例和对照组30例。对照组患者口服布洛芬缓释胶囊1粒,0.3 g/粒,早晚各1次,必要时加用钙离子拮抗剂;治疗组患者口服川芎清脑颗粒,1袋/次,10 g/袋,3次/d。两组均以14 d为1个疗程,连续治疗2个疗程。分别于15 d、1个月、2个月进行随访,观察偏头痛的改善情况(发作次数、发作程度、持续时间、伴随症状、综合评分、不良反应)。结果:治疗15 d后,治疗组偏头痛改善情况与对照组比较,差异无统计学意义(P>0.05);治疗1个月后,治疗组偏头痛改善情况与对照组比较,差异有统计学意义(P<0.05);治疗2个月后,治疗组偏头痛改善情况与对照组比较,差异有统计学意义(P<0.05)。治疗组总有效率高于对照组(P<0.05)。不良反应未经处理均自行消失。结论:川芎清脑颗粒治疗偏头痛效果好,不良反应少。OBJECTIVE：To observe the clinical effect of Chuanxiong qingnao granules in the treatment of migraine. METHODS：59 patients with migraine collected from our hospital during Apr.-Nov. 2013 were randomly divided into trial group（29 cases）and control group（30 cases）. The control group was given Ibuprofen sustained-released capsule orally,0.3g/capsule,one capsule each time,twice a day,morning and night,and additionally received Calcium antagonists if necessary. The trial group took Chuanxiong qingnao granules orally,10 g/bag,one bag each time,3 times a day. A treatment course lasted for 14 days,and both received 2treatment courses of therapy. In 15 days,one month,two months follow-up,the occurrence of migraine was observed（attack frequency,intensity,time of onset,associated symptoms and ADR）. RESULTS：After 15 days of treatment,there was no statistical significance in the improvement of migraine between trial group and control group（P〉0.05）. After a month of treatment,there was statistical significance in the improvement of migraine between trial group and control group（P〈0.05）. After 2 months of treatment,there was statistical significance in the improvement of migraine between trial group and control group（P〈0.05）. Total effective rate of trial group was higher than that of control group（P〈0.05）. All ADR disappeared without any treatment. CONCLUSIONS：Chuanxiong qingnao granules are effective in the treatment of migraine with less ADR.

关 键 词：偏头痛 川芎清脑颗粒 中药疗法 

分 类 号：R74[医药卫生—神经病学与精神病学] R747.2[医药卫生—临床医学]