原发性卵巢甲状腺肿类癌4例临床病理分析  

The clinical pathology analysis of primary ovarian strumal carcinoid in 4 cases

作　　者：胡怀远[1] 雍翔 宋瑞[1] 张辉[1] 武雪芹[1] 刘岩[1] 

机构地区：[1]皖北煤电集团总医院病理科,安徽宿州234000

出　　处：《蚌埠医学院学报》2014年第9期1173-1176,共4页Journal of Bengbu Medical College

摘　　要：目的:探讨原发性卵巢甲状腺肿类癌(POSC)的临床病理特征。方法:应用光镜、免疫组织化学、特殊染色技术对4例POSC进行临床病理分析。结果:患者临床表现为腹痛及盆腔肿块,无便秘、类癌综合征表现,其中2例以卵巢囊状肿块蒂扭转为首发症状。组织学上甲状腺肿与类癌相移行,部分类癌细胞排列成岛状或梁状,1例伴有交界性黏液性囊腺瘤成分,3例伴有成熟性畸胎瘤。免疫表型:类癌细胞神经细胞黏附分子、突触素、嗜铬素、神经元特异性烯醇化酶均阳性。结论:POSC是一种罕见的生殖细胞肿瘤,形态学上需要与卵巢粒层细胞瘤、Sertoli-Leydig细胞瘤等相鉴别,HE切片及免疫组织化学标记可以有效地帮助诊断。Objective： To investigate the clinicopathological characteristics of primary ovarian strumal carcinoid （POSC）. Methods ： The clinicopathological characteristics of POSC in 4 cases were analyzed by light microscopy, immunohistochemistry and special stains. Results ：The patients＇ clinical manifestations were lower abdominal pain, and no constipation and careinoid syndrome. Ovarian cystic masses torsion was the initia symptom in 2 cases. The goiter and carcinoid tissue were transition, part cancer cells arranged in island or beam. The borderline mucinous cystadenoma in 1 case and mature teraloma in 3 cases were found. The neural cell adhesion molecule of immune phenotype cancer cells, synaptophysin, chromogranin and neuron specific enolase were positive. Conclusions： POSC is a rare germ cell tumor, which should be differentiated from granulosa cell tumor and Sertoli-Leydig cell tumor. HE and immunohistochemical stain will contribute to the diagnosis.

关 键 词：卵巢肿瘤 甲状腺肿类癌 免疫组织化学 病理 临床 

分 类 号：R737.31[医药卫生—肿瘤]