HPV感染及HLA多态性与宫颈癌相关性研究进展  

Research Progress of Relationships among HPV Infection,HLA Polymorphism and Cervical Cancer

作　　者：赵俊玲[1] 王若峥[1] 

机构地区：[1]新疆医科大学附属肿瘤医院头颈放疗科,乌鲁木齐830011

出　　处：《医学综述》2014年第18期3306-3308,共3页Medical Recapitulate

基　　金：国家国际科技合作专项项目(2012DFA31560)

摘　　要：目前大量研究表明,高危型人乳头瘤病毒(HPV)的持续感染是宫颈癌发生的主要病因,尤其是HPV16、18型,然而单纯HPV感染不足以引起宫颈癌的发生,还需要其他分子事件的共同参与。近年来的研究证实,环境因素、生活方式、宿主的免疫和遗传学背景均在宫颈癌的发生中起着重要作用,而人类白细胞抗原(HLA)正是作为宿主的免疫及遗传学背景参与了HPV感染及宫颈癌的疾病演变过程,且已发现部分HLA基因多态性与不同地区、不同人种HPV感染及宫颈癌的遗传易患性相关。At present a large number of studies have shown that high-risk human papillomavirus（HPV） persistent infection is a major cause of cervical cancer,especially HPV 16,18 type,however,HPV infection alone is not sufficient to cause cervical cancer,the participation of other molecular events is also part of the process.Recent studies have demonstrated that environmental factors,lifestyle,and the immune and genetic background of the host all play an important role in cervical cancer,and HLA is involved in HPV infection and cervical cancer progression precisely as the host immune and genetic background,and it has been found that some HLA gene polymorphism are associated with the genetic susceptibility of HPV infection and cervical cancer of different regions and ethnic groups.

关 键 词：人乳头瘤病毒 人类白细胞抗原 多态性 宫颈癌 

分 类 号：R737.33[医药卫生—肿瘤]