癌症中DNA甲基化基因模块筛选  

The screening of DNA methylation gene modules in cancers

作　　者：张淑梅[1] 张彬[1] 刘军厚 刘洪波[1] 苏建忠[1] 王芳[1] 张岩[1] 

机构地区：[1]哈尔滨医科大学生物信息科学与技术学院,黑龙江哈尔滨150081

出　　处：《生物信息学》2014年第3期189-195,共7页Chinese Journal of Bioinformatics

基　　金：黑龙江省大学生创新创业训练计划(201210226050)资助

摘　　要：肿瘤的发生受遗传学和表观遗传学修饰的共同影响。DNA甲基化是一种重要的表观遗传修饰,在癌症的发生与发展中起着重大的作用。因此找到癌症的甲基化标记物在癌症的诊断和治疗中具有重大意义。本文利用权重基因共表达网络分析的方法(WGCNA)筛选出甲基化基因模块,并分析模块向量基因,进行功能注释,最后对基因模块进行功能分析,得到DNA甲基化与肿瘤间的关系。结果显示,这些甲基化异常的基因模块与癌症的发生有着显著的关联。同时还发现某些甲基化异常的基因模块与多种癌症的发生都有着显著的关联。Tumorigenesis is affected by both genetic and epigenetic modifications. DNA methylation acts as an important epigenetic modification and plays a major role in the occurrence and development of cancers. Therefore, finding the methylation biomarkers in cancers is a great feat in the diagnosis and treatment of cancers. In this paper, we take the advantage of Weight Gene Co-expression Network Analysis method（ WGCNA） to filter out methylation gene modules and analyze the module vector genes, afterwards, the functional annotation, then we conduct functional analysis of gene modules, finally the relationship between DNA methylation and cancers can be interpreted. The results showed that these aberrant methylated gene modules have significant associations with cancers. Interestingly,we also found that some abnormal methylation gene modules have great associations with the occurrences of various cancers.

关 键 词：表观遗传修饰 肿瘤 甲基化 WGCNA 基因模块 

分 类 号：Q81[生物学—生物工程]