89SrCL2与唑来膦酸联合治疗乳腺癌转移性骨肿瘤的疗效分析  

Analysis on the curative effect of combination therapy with zoledronic acid and 89SrCL2 on bone tumor with breast cancer metastasis

作　　者：刘超[1] 邓智勇[1] 刘鹏杰[1] 贾莉[1] 

机构地区：[1]云南省肿瘤医院核医学科,昆明650118

出　　处：《国际放射医学核医学杂志》2014年第5期300-303,共4页International Journal of Radiation Medicine and Nuclear Medicine

摘　　要：目的：探讨放射性核素二氯化锶（89SrCl2）联合唑来膦酸治疗激素依赖型乳腺癌转移性骨肿瘤的临床疗效。方法回顾性分析64例激素依赖型乳腺癌转移性骨肿瘤患者的临床资料，将所有患者分为3组：89SrCl2治疗组22例；唑来膦酸治疗组21例；89SrCl2联合唑来膦酸治疗组21例；观察治疗后转移病灶疗效、骨痛缓解情况、生活质量状况、骨髓抑制反应情况。结果89SrCl2治疗骨转移病灶有效率为36.4%（8/22），视觉模拟评分下降率为77.3%（17/22），全身状况KPS评分提高率为63.6%（14/22），27.2%（6/22）的患者出现骨髓抑制反应；唑来膦酸治疗后骨转移病灶有效率为33.3%（7/21），视觉模拟评分下降率为71.4%（15/21），全身状况KPS评分提高率为52.4%（11/21），19.0%（4/21）的患者出现骨髓抑制反应；89SrCl2联合唑来膦酸治疗骨转移病灶有效率为42.9%（9/21），视觉评分下降率为90.5%（19/21），全身状况KPS评分提高率为90.5%（19/21），33.3%（7/21）的患者出现骨髓抑制反应。结论89SrCl2联合唑来膦酸对激素依赖型乳腺癌转移性骨肿瘤的疗效明显，不良反应小，联合治疗效果优于89SrCl2和唑来膦酸单独治疗。Objective To discuss the clinical effects of radionuclide 89SrCl2 combined zoledronic acid treatment for hormone dependent breast neoplasm metastatic osteoma. Methods Clinical data of 64 patients with hormone dependent breast neoplasm metastatic osteoma were analyzed retrospectively. All of these patients were divided into 3 groups：one group of 22 cases treated with 89SrCl2（89SrCl2 group）;another group of 21 cases treated with zoledronic acid（zoledronic acid group）;and the last group of 21 cases treat-ed with 89SrCl2 and zoledronic acid（combination group）. Then patients′metastatic lesion curative effects, the condition of bone pain remission, quality of life and bone marrow inhibitory reaction after treatment were observed. Results The effective rate, visual analogue scale decline rate, whole body KPS score in-crease rate and bone marrow inhibitory reaction rate of the 89SrCl2 group were 36.4%（8/22）, 77.3%（17/22）, 63.6%（14/22）, 27.2%（6/22）, and which were 33.3%（7/21）, 71.4%（15/21）, 52.4%（11/21）, 19.0%（4/21） and 42.9%（9/21）, 90.5%（19/21）, 90.5%（19/21）, 33.3%（7/21） in zoledronic acid group and combination group respectively. Conclusion 89SrCl2 combined with zoledronic acid on treating hormone dependent breast neoplasm metastatic osteoma has significant curative effect, and can relieve pain with less adverse reactions, and the combined treatment effects are better than that of 89SrCl2 or zoledronic acid alone.

关 键 词：乳腺肿瘤 肿瘤转移 骨肿瘤 二氯化锶 唑来膦酸 89SrCl2 

分 类 号：R737.9[医药卫生—肿瘤] R817.5[医药卫生—临床医学]