阿尔茨海默病PET正电子药物应用与研究进展  

Application and research progress of PET positron tracers associated with Alzheimer disease

作　　者：段小艺[1] 李淼[1] 王黎[1] 李宏利[2] 赵周社[2] 郭佑民[1] 

机构地区：[1]西安交通大学第一附属医院PET/CT室,710061 [2]GE医疗系统集团中国,北京100176

出　　处：《国际放射医学核医学杂志》2014年第5期318-322,共5页International Journal of Radiation Medicine and Nuclear Medicine

摘　　要：阿尔茨海默病（AD）严重危害人们的身心健康。伴随PET分子成像的发展，出现了一系列针对AD的正电子药物，其中匹兹堡化合物B（PIB）及其衍生物类PET正电子药物研究最为成熟，部分已获准应用于临床，在AD诊断与治疗方面显示出重要价值。随着人们对AD发生机制研究的不断深入，近年又相继出现了包括蛋白类、受体类以及肽类在内的更多种类AD相关PET正电子药物。该文就此类正电子药物的应用与研究进展做一综述。Alzheimer disease（AD） harms human being′s health seriously. With the development progress of PET molecular imaging, a series of PET positron tracers associated with AD appeard. Among them, pittsburgh compound-B（PIB） and PIB derivatives are studied more deeply and part of them have been used in clinic which are showing great value in diagnosis and therapy of AD. Recently, with the deep-er research of AD mechanism , more kinds of PET tracers related to AD are developed, including protein , receptor and peptide radiotracers. This article reviews the current application and research progress of those PET positron tracers which associated with AD.

关 键 词：阿尔茨海默病 正电子发射断层显像术 正电子药物 

分 类 号：R749.16[医药卫生—神经病学与精神病学]