Wnt/β-catenin信号通路在肝癌发病机制中作用的研究  

Relationship between Wnt /β-catenin signaling pathway and hepatocellular carcinoma

作　　者：刘佳[1] 张明娟[1] 朱琴梅[1] 王甦[1] 

机构地区：[1]扬州大学医学院附属苏北人民医院消化内科,江苏扬州225001

出　　处：《胃肠病学和肝病学杂志》2014年第9期994-997,共4页Chinese Journal of Gastroenterology and Hepatology

摘　　要：Wnt/β-catenin信号通路也称Wnt经典信号通路,参与调控细胞分化、癌变、凋亡及机体免疫、应激等多种病理生理过程。有研究表明Wnt信号通路与肝癌(hepatocellular carcinoma,HCC)的发生相关。深入研究Wnt/β-catenin信号通路在肝癌发病中的作用,将有助于进一步揭示肝癌的发病机制,为肝癌的防治提供新的可能途径及干预靶点。Wnt/β-catenin signaling pathway participates in many physiological and pathological processes such as cell differentiation,carcinogenesis,apoptosis,immunity and stress.Several studies have shown that Wnt/β-catenin signaling pathway is involved in the formation of hepatocellular carcinoma （HCC）.Elucidation of the relationship between Wnt/β-catenin signaling pathway and hepatocellular carcinoma will certainly provide a new insight into the pathogenesis and a new anticancer therapy of hepatocellular carcinoma.

关 键 词：WNT/Β-CATENIN信号通路 肝癌 发病机制 

分 类 号：R735.7[医药卫生—肿瘤]