酒精依赖综合征治疗药物的研究进展  

Research progress on therapeutic agents for alcohol dependence syndrome

作　　者：魏守鹏 梁建辉[1] 

机构地区：[1]北京大学中国药物依赖性研究所,北京100191

出　　处：《中国药理学通报》2014年第10期1333-1337,共5页Chinese Pharmacological Bulletin

基　　金：十二五科技支撑计划资助项目(No 2011BAK04B08)

摘　　要：当今社会生活中酒精滥用现象普遍存在,已成为危害人类健康与公共安全的医学和社会难题。目前研发的多种活性物质能够影响中脑边缘多巴胺神经通路以降低酒精引起的奖赏效应,从而有效改善或治疗酒精依赖综合征。该文综述了近期酒精依赖干预药物的研究进展,旨在为相关机制研究和药物开发提供参考。Alcohol is widely abused in contemporary social life, which has become a serious medical and social problem because it hurts human health and endangers public safety. Recent re-search has developed several active substances that can effective-ly improve or treat this syndrome via affecting the mesolimbic do-pamine nervous pathway to dampen rewarding effectiveness in-duced by ethanol. This paper reviews the progress in near-term studies of alcoholism-intervening agents, aiming at providing ref-erences for related mechanism exploration and drug development.

关 键 词：酒精依赖综合征 治疗药物 奖赏通路 伏核 受体 多巴胺 

分 类 号：R-05[医药卫生] R442.8