Kv7(KCNQ)钾离子通道对中枢单胺能神经传递的调控  

Kv7 channels in modulation of central monoaminergic neurotransmission

作　　者：赵晨[1] 张海林[1] 

机构地区：[1]河北医科大学药理学教研室,河北石家庄050017

出　　处：《中国药理学通报》2014年第10期1350-1353,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 31270882);国家重点基础研究发展计划"973"子计划课题(No 2013CB531302)

摘　　要：KCNQ基因编码5种Kv7钾离子通道亚型(Kv7.1-Kv7.5),其中4种(Kv7.2-Kv7.5)表达于中枢神经系统内。神经元Kv7通道参与突触前后神经递质的调节,激活Kv7通道能够降低神经元兴奋性,减少单胺类神经递质释放,Kv7通道开放剂为单胺类神经元过度兴奋所致疾病(如精神分裂、焦虑、药物滥用等)提供了新的治疗方案,该文将针对Kv7通道在单胺类神经系统内的表达、功能及Kv7通道开放剂在治疗神经元过度兴奋所致疾病中的作用进行总结。The KCNQ gene family encodes five Kv7 channel sub-units（Kv7. 1-5） and four of these （Kv7. 2-5） channels are ex-pressed in the central nervous system （ CNS ） . Neuronal Kv7 channels participate in both pre-and post-synaptic modulation of neurotransmissions. Activation of neuronal Kv7 channels inhibits neuronal excitability and limits the release of monoaminergic neu-rotransmitter. Kv7 channel openers provide novel therapeutic op-tions in the treatment of disease states characterized by overactiv-ity of monoaminergic neurons （ e. g. schizophrenia, anxiety and drug abuse） . This review summarizes the studies on expression and functional role of Kv7 channels in monoaminergic neurotrans-mission in the CNS and the potential therapeutic effect of Kv7 channel openers on the disease characterized by overactivity of monoaminergic neurons.

关 键 词：Kv7钾离子通道 KCNQ基因 单胺类神经系统 瑞替加滨 神经元 兴奋性 疾病 

分 类 号：R-05[医药卫生] R322.81