Ⅰ型胶原／HA／rhBMP-2复合材料原位修复甲状软骨缺损的实验研究  

Experimental study ofⅠcollagen/HA/rhBMP-2 composite materials in situ repair of thyroid cartilage defects

作　　者：胡万青[1] 张龙城 夏薇[3] 曹高翔[3] 

机构地区：[1]马鞍山市人民医院耳鼻咽喉科,安徽马鞍山243000 [2]解放军三0三医院耳鼻咽喉头颈外科,安徽马鞍山243000 [3]广西大学材料科学与工程学院,安徽马鞍山243000

出　　处：《临床耳鼻咽喉头颈外科杂志》2014年第18期1407-1410,共4页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基　　金：全军医药卫生科研基金(No:06MA122):骨形态发生蛋白复合物结合CAD/CAM技术修复喉气管软骨缺损;广西自然科学基金项目(No:2011GXNSFA018209):基于逆向工程的喉气管软骨支架个体化三维实体重建研究

摘　　要：目的:以Ⅰ型胶原、羟基磷灰石(HA)、重组人骨形态发生蛋白-2(rhBMP-2)为材料,制作人工材料支架修复兔甲状软骨缺损,寻求一种原位修复甲状软骨缺损的新途径。方法:实验动物分为3组,实验组以Ⅰ型胶原、HA、rhBMP-2为材料;对照组以Ⅰ型胶原、HA为材料,分别进行甲状软骨缺损的原位修复;空白组直接切除一侧甲状软骨。通过大体观察、组织学观察其修复效果。结果:Ⅰ型胶原/HA/rhBMP-2复合材料支架能够原位诱导成骨。结论:Ⅰ型胶原/HA/rhBMP-2复合材料可作为一种新型的、具有良好生物活性的材料为临床甲状软骨缺损的修复和重建打下基础。Objective:TypeⅠcollagen,hydroxyapatite(HA),recombinant human bone morphogenetic protein-2(rhBMP-2)for the material,production of artificial scaffold repairing rabbit thyroid cartilage defects,seeking a new way of in situ remediation of thyroid cartilage defects.Method:Experimental animals were divided into three groups,the experimental groupⅠ collagen,HA,rhBMP-2for the material,the control groupⅠ collagen,HA for the material,respectively,of the thyroid cartilage defects in situ remediation;blank side with direct removal of the thyroid cartilage.By gross observation,histological its restorative effects.Result:Ⅰcollagen/HA/rhBMP-2situ composite scaffold can induce osteogenesis.Conclusion:Ⅰcollagen/HA/rhBMP-2composite materials can be used as a novel,biologically active material with good clinical thyroid cartilage defect repair and rebuild the foundation.

关 键 词：I型胶原 羟基磷灰石 重组人骨形态发生蛋白-2 原位修复 甲状软骨 

分 类 号：R736[医药卫生—肿瘤]