人乳头瘤病毒16E5突变与宫颈癌的研究进展  

HPV16E5 Gene Mutation and Cervical Cancer Research Progress

作　　者：杨丹[1] 玛依努尔尼牙孜 朱开春 梁媛哲 亚力坤 

机构地区：[1]新疆自治区人民医院,新疆乌鲁木齐830000 [2]新疆自治区人民医院妇产科研究室,新疆乌鲁木齐830000

出　　处：《现代生物医学进展》2014年第32期6395-6397,共3页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(81160317)

摘　　要：人乳头瘤病毒(Humanpapillomavirus)HPV是发生宫颈癌的必要条件,人乳头瘤病毒16E5癌基因突变与宫颈癌的发生有密切的相关性。人乳头瘤病毒E5是一种转化作用的癌蛋白,是细胞膜或内膜整合蛋白。人乳头瘤病毒E5在感染的细胞中表达。主要在感染细胞克隆早期的繁殖,扩张中起重要作用。它干预生长因子受体,干扰周期蛋白和周期蛋白激酶,促进病毒癌基因转化,抑制抑癌基因表达,激活启动子促进病毒繁殖,并通过多种机制促使损伤细胞,通过细胞周期,使宿主细胞增殖,分化延缓,恶性化。E5基因变异意味着功能有可能改变,可能机体或细胞对病毒变异株的免疫能力,与宫颈癌的发生和HPV的嗜上皮性有关,因此对人乳头瘤病毒16E5基因变异的研究对于人乳头瘤病毒16在宫颈癌发病中的作用有着不可忽略的意义。本文对人乳头瘤病毒16E5突变株在宫颈癌组织中的作用及其基因突变的研究现状进行分析。Humanpapillomavirus DNA is necessary for the development of cervical carcinoma, there are closely relation between the virants of Humanpapillomavirus 16E5 oncogene and cervical carcinoma.Human papillomavirus oncoprotein E5 is a conversion function, the integration of cell membranes or endometrial protein. Human papillomavirus E5 expression in infected cells, mainly in the infected cell clones early breeding, play an important role in the expansion. And interfere with the growth factor receptor, interference cycle proteins and cyclin kinase promote viral oncogene transformation, inhibit the expression of tumor suppressor genes, activate the promoter for virus propagation and damage cells through a variety of mechanisms to promote the host cell through the cell cycle, proliferation, differentiation delay malignancy. The E5 gene variation means that the function may change possible body or the cells mutant virus immunity, with the occurrence of cervical cancer and the HPV addicted epithelial, so Human papillomavirus 16E5 gene variants have a non-negligible significance for human papillomavirus 16cervical cancer, this article give research for function and current study of Humanpapillo- mavirus 16E5 virants in cervical carcinoma.

关 键 词：人乳头瘤病毒(Humanpapillomavirus)HPV 宫颈癌 E5基因突变 

分 类 号：R737.31[医药卫生—肿瘤]