Correlation of ADC value with pathologic indexes in colorectal tumor homografts in Balb/c mouse  

作　　者：Xiaojun Li Hongnan Jiang Jinliang Niu Ying Zheng 

机构地区：[1]Department of Radiology,the 2nd Hospital of Shanxi Medical University [2]Department of Breast Surgery,the 2nd Hospital of Shanxi Medical University

出　　处：《Chinese Journal of Cancer Research》2014年第4期444-450,共7页中国癌症研究（英文版）

摘　　要：Objective： Noninvasive diffusion-weighted magnetic resonance imaging （DWI） is a well-studied MR imaging technique for quantifying water diffusion especially in tumor area. The correlation between apparent diffusion coefficient （ADC） value and apoptosis or proliferation is not clear by now. This study aimed to investigate whether DWI-ADC value could be used as an imaging marker related with pathologic indexes of tumors. Methods： A total of 3 0 Balb/c mice with HT2 9 colorectal carcinoma were subjected to DWI and histologic analysis. The percentage of ADC changes and the apoptotic and proliferating indexes were calculated at predefined time points. Kolmogorov-Smirnov distances were considered to determine whether the percentage of ADC changes, and the apoptotic and proliferating indexes were normally distributed. An independent-samples t-test was used to analyze the difference between apoptotic and proliferating indexes in the two groups. Results： There was a statistically significant difference in proliferating index between the radiotherapy and control groups （mean proliferating index： 49.27% vs. 83.09%）, and there was a statistically significant difference in apoptotic index between the two groups （mean apoptotic index： 37.7% vs. 2.71%）. A significant positive correlation was found between the percentage of ADC changes of the viable tissue and apoptotic index. Pearson＇s correlation coefficient was 0.655 （P=0.015）. A significant negative correlation was found between the percentage of ADC changes of the viable tissue and ki-67 proliferation index. Pearson＇s correlation coefficient was 0.734 （P〈0.001）. Conclusions： Our results suggest that ADC proliferating indexes in colorectal carcinoma. value may be used in measurement of cell apoptotic andObjective： Noninvasive diffusion-weighted magnetic resonance imaging （DWI） is a well-studied MR imaging technique for quantifying water diffusion especially in tumor area. The correlation between apparent diffusion coefficient （ADC） value and apoptosis or proliferation is not clear by now. This study aimed to investigate whether DWI-ADC value could be used as an imaging marker related with pathologic indexes of tumors. Methods： A total of 3 0 Balb/c mice with HT2 9 colorectal carcinoma were subjected to DWI and histologic analysis. The percentage of ADC changes and the apoptotic and proliferating indexes were calculated at predefined time points. Kolmogorov-Smirnov distances were considered to determine whether the percentage of ADC changes, and the apoptotic and proliferating indexes were normally distributed. An independent-samples t-test was used to analyze the difference between apoptotic and proliferating indexes in the two groups. Results： There was a statistically significant difference in proliferating index between the radiotherapy and control groups （mean proliferating index： 49.27% vs. 83.09%）, and there was a statistically significant difference in apoptotic index between the two groups （mean apoptotic index： 37.7% vs. 2.71%）. A significant positive correlation was found between the percentage of ADC changes of the viable tissue and apoptotic index. Pearson＇s correlation coefficient was 0.655 （P=0.015）. A significant negative correlation was found between the percentage of ADC changes of the viable tissue and ki-67 proliferation index. Pearson＇s correlation coefficient was 0.734 （P〈0.001）. Conclusions： Our results suggest that ADC proliferating indexes in colorectal carcinoma. value may be used in measurement of cell apoptotic and

关 键 词：Diffusion-weighted magnetic resonance imaging （DWI） apparent diffusion coefficient （ADC） apoptosis proliferation HT29 

分 类 号：R735.34[医药卫生—肿瘤]