Wallenberg综合征患者椎动脉发育不良现象相关临床研究  

Clinical research of Wallenberg syndrome in patients with vertebral artery hypoplasia

作　　者：王建[1] 段丹[1] 王庆松[1] 郑波[1] 郁可[1] 王志强[2] 

机构地区：[1]成都军区总医院神经内科,四川成都610083 [2]第三军医大学研究生管理大队,四川成都610083

出　　处：《中风与神经疾病杂志》2014年第9期826-829,共4页Journal of Apoplexy and Nervous Diseases

基　　金：四川省卫生厅科研课题(090005);成都军区医学科研"十二五"第一批次计划研究项目(C12045);成都军区总医院重点研究项目(2013YG-A006)

摘　　要：目的利用全脑数字减影血管造影术（DSA）探讨Wallenberg综合征发病与椎动脉优势及发育不良现象之间的相关性。方法将37例Wallenberg综合征患者设为观察组,148例前循环脑梗死患者设为对照组,有所患者都进行DSA检查,对比检测两组患者中出现椎动脉优势（vertebral artery dominance,VAD）及椎动脉发育不良（vertebral artery hypoplasia,VAH）现象的分布差异,分析其血管变异与Wallenberg综合征的相互关联及优势比（0dds ratio,OR）。结果观察组中有VAD现象19例（包含4例右侧发育不良,2例左侧发育不良）;对照组中有VAD现象45例（包含3例右侧发育不良,3例左侧发育不良）。观察组中VAD、椎动脉发育不良的出现率均高于对照组（分别为χ2=5.739,P=0.017;χ2=5.352,P=0.021）,差异具有统计学意义（P〈0.05）;其中VAD、VAH的几率较对照组明显增高（OR=2.416,95%CI 1.160-5.032,OR=4.581,95%CI 1.385-15.154）。结论 VAD、VAH现象与Wallenberg综合征间存在一定的关联,在其发病中可能有较为重要的意义。Objective By using the whole brain digital subtraction angiography（ DSA） to investigate the Wallenberg syndrome pathogenesis and the correlation between unilateral vertebral artery dominance and vertebral artery hypoplasia. Methods 37 patients with Wallenberg syndrome were set as observation group,148 cases of Before the circulation infarction,all patients had DSA examination and analysis in the two groups of patients with unilateral vertebral artery dominance（ VAD） and vertebral artery hypoplasia（ VAH） distribution difference of phenomena,analyze its vascular variation correlated with Wallenberg syndrome and odds ratio（ OR）. Results The observation group have19 cases in the VAD phenomenon（ including 4 cases of right dysplasia,2 cases left dysplasia）; 45 cases in control group VAD occurs（ including 3cases on the right side of dysplasia,3 cases on the left side of the dysplasia）. VAD and vertebral artery hypoplasiain in observation groupare higher than the control group（ χ2= 5. 739,P = 0. 017; χ2= 5. 352,P = 0. 021,respectively）,The difference have statistical significance（ P 〈0. 05）; The risk of the VAD and VAH increased significantly（ OR = 2. 416,95% CI1. 160 - 5. 032,OR = 4. 581,95% CI1. 385 - 15. 154）. Conclusions Between Wallenberg syndromeand VAD or VAH have significant correlation. It may be an important significance in its pathogenesis.

关 键 词：WALLENBERG综合征 DSA VAD VAH 

分 类 号：R743[医药卫生—神经病学与精神病学]