丁苯酞软胶囊治疗血管性痴呆的疗效以及对VEGF的影响  

The Clinical Efficacy and the Effect on the Level of VEGF of Butylphthalide in the Treatment of Vascular Dementia

作　　者：李卫征[1] 张慧敏[1] 

机构地区：[1]河南省新乡市中心医院神经内科,河南新乡453000

出　　处：《中国伤残医学》2014年第19期20-21,共2页Chinese Journal of Trauma and Disability Medicine

摘　　要：目的：观察丁苯酞软胶囊治疗血管性痴呆患者的临床疗效及对血管内皮生长因子（ VEGF）的影响。方法：将94例血管性痴呆患者随机分为丁苯酞软胶囊治疗组和对照组，对所有患者治疗前后采用MMSE、ADL评分进行认知能力及日常生活能力评估。并检测2组治疗前后VEGF的变化。结果：治疗组治疗后MMSE、ADL评分均优于对照组，治疗组治疗后总有效率明显高于对照组，治疗后治疗组VEGF水平明显升高，2组均有显著差异（p＜0．05）。结论：丁苯酞软胶囊能够显著改善血管性痴呆患者的症状，其作用机制可能与提高VEGF水平有关。Objective：To study the clinical efficacy and the effect on the value of serum VEGF level of butylphthalide in the treatment of vascular dementia .Methods：94 patients with vascular dementia were randomly divided into butylphthalide treatment group and control group.MMSE scales and ADL scales were used to assess cognitive dysfunction ,daily living activities .The level of VEGF were measured in all patients before and after treatment .Results：MMSE scales and ADL scales in the butylphthalide group were better than that in the control group（p〈0.05）, the effective rate and the level of VEGF in the butylphthalide group was higher than that in the control group （p〈0.05）.Conclusion：Butylphthalide can effective improve cognitive dysfunction and daily living activities .Furthermore, butylphthalide can improve the level of VEGF .

关 键 词：血管性痴呆 丁苯酞 血管内皮生长因子 

分 类 号：R743[医药卫生—神经病学与精神病学]