合肥地区轻度认知功能障碍的流行病学调查及叶酸的干预效果  

The epidemiology of mild cognitive impairment and intervention effect of folic acid in Hefei

作　　者：顾辨辨[1,2] 严光[1,2] 周树生 

机构地区：[1]安徽医科大学附属省立医院 [2]安徽省立医院老年医学科,合肥230001 [3]安徽省立医院重症医学科,合肥230001

出　　处：《中国临床保健杂志》2014年第5期475-477,共3页Chinese Journal of Clinical Healthcare

基　　金：安徽省国际科技合作计划项目(11030603025)

摘　　要：目的对合肥地区轻度认知功能障碍(MCI)患病情况进行流行病学调查,并观察叶酸对MCI的干预治疗效果。方法调查合肥地区多所医院就诊的679名患者的MMSE值和血清同型半胱氨酸(Hcy)水平,根据简易精神状态评价量表(MMSE)评分值分为正常老年组(A组),轻度认知功能障碍组(B组)及痴呆组(C组),其中B组根据有无叶酸治疗,分为治疗组(B1组)和非治疗组(B2组)。观察A组、B1组及B2组患者的MMSE值变化及Hcy值,随访时间为3年。结果 679名老年人中,其中正常老年人560人,MCI92人,痴呆者27人。随访期内,A组47例新发MCI,B1组10例、B2组16例新发痴呆。MCI患者未予干预组3年内有36.36%进展为痴呆;叶酸干预组痴呆三年患病率为20.83%。结论合肥地区60岁以上的老人MCI和痴呆患病率较高,补充叶酸可延缓MCI患者病情进展。Objective To investigate the prevalence of mild cognitive impairment（ MCI） in hefei,and observe the intervention effect of folic acid for MCI. Method Six hundreds and seventy nine patients were selected from multiple hospital according MMSE and the level of homocysteine. On the basis of MMSE scores,the patients were divided into normal group（ A）,MCI group（ B） and dementia group（ C）. The MCI group was divided into the treatment group（ B1） and non- treatment group（ B2）. The MMSE value and Hcy levels were follow- up three years.Results Six hundreds and seventy nine elderly people were surveyed,including 560 normal elderly,92 MCI and 27 dementia patients. Forty-seven new cases of MCI were detected in group A. Ten and sixteen new cases of dementia were developed from MCI in B1 and B2 group. The 36. 36% MCI patients were developed into dementia in control group,and 20. 83% MCI patients were developed into dementia in intervention group after 3 years. Conclusion The prevalence of MCI and dementia are higher in Hefei elderly. The supplementation of folic acid can retard the progress of MCI.

关 键 词：轻度认知障碍 患病率 半胱氨酸 叶酸 

分 类 号：R749.1[医药卫生—神经病学与精神病学]