基于电子医疗病例的缺血性中风病药物群组模块思路探讨  

Explore ideal of establishing ischemic stroke drugs group modules based on electronic medical records

作　　者：杨薇[1] 谢雁鸣[1] 

机构地区：[1]中国中医科学院中医临床基础医学研究所,北京100700

出　　处：《中国中药杂志》2014年第18期3430-3434,共5页China Journal of Chinese Materia Medica

基　　金：国家"重大新药创制"科技重大专项(2009ZX09502030);中国中医科学院基本科研业务费自主选题项目(ZZ0808016);中国中医科学院博士研究生创新人才培养基金项目

摘　　要：缺血性中风病是高发病率、高病死率、高致残率的临床常见病多发病,临床实践中大型综合医院治疗缺血性中风病急性期时常同时使用多种中西药物,依据生物学"模块化理论",不同特征的患者使用药物也有所不同,同为治疗该种疾病的药物组合之间可能具有多种拓扑结构特征,即模块(modular)。该研究提出在全国20家大型综合医院的电子医疗病例组成的数据库中,建立缺血性中风病急性期药物复杂网络,采用复杂网络分析及数据挖掘等方法,探索建立针对不同缺血性中风病患者人群的若干个中西药物群组模块,阐释其结构与功能特点,探索适宜人群并评价药物群组模块在临床使用中的有效性及安全性,为优化缺血性中风病临床治疗方案提供方向,为联合用药研究提供新的方法,也为中西药物联合使用方案进入指南提供依据。Ischemic stroke is a kind of common and frequently-occurring disease in clinic.It has high morbidity and high mortality and high morbidity characteristics.It was treated may also use a variety of Chinese and western medicine in the acute phase in the large general hospital in clinical practice.According to the ＂modularity theory＂ from biology,different patients using different drugs,and with combination of drugs for the treatment of this disease may have a variety of topological structure characteristics.This study proposed in the national 15 large general hospital electronic medical records of database,the complex network constructed by acute ischemic stroke disease using drugs,adopting to the complex network analysis and data mining methods to build for different ischemic stroke patients who are many of Chinese and western medicine group modules.These modules can be explained structure and function characteristics,and to explore the appropriate crowd and evaluate drug group module efficacy and safety in use in clinic.It provide direction to optimize the clinical treatment for ischemic stroke,provide new method for the research on combination,also provide the basis for drug combination of Chinese and western solution into the guide.

关 键 词：缺血性中风病 药物群组模块 电子医疗病例 复杂网络 

分 类 号：R743.3[医药卫生—神经病学与精神病学]