肾透明细胞癌中KISS-1、VEGF的表达及其临床意义  

KISS-1 and VEGF Expression in Renal Clear Cell Carcinoma and Its Clinical Significance

作　　者：袁帅[1] 潘梦音[1] 冯凯祥[1] 景东帅 谢明红[1] 李世朋[2] 韩洪波[1] 

机构地区：[1]河南科技大学医学院,河南洛阳471003 [2]天津医科大学一中心临床学院,天津300192

出　　处：《河南科技大学学报（医学版）》2014年第3期167-169,共3页Journal of Henan University of Science & Technology:Medical Science

基　　金：河南科技大学大学生训练计划(SRTP)项目(2012186)

摘　　要：目的探讨肿瘤抑制因子KISS-1蛋白和血管内皮生长因子VEGF在肾透明细胞癌组织中的表达及临床意义。方法采用免疫组织化学法检测31例肾透明细胞癌组织和15例正常肾组织中KISS-1蛋白和VEGF的表达。结果在肾透明细胞癌组织和正常肾组织中KISS-1蛋白阳性表达率分别为29.0%和60.0%,差异有统计学意义(P﹤0.05);在肾透明细胞癌组织和正常肾组织中VEGF阳性表达率分别为80.6%和46.7%,差异有统计学意义(P﹤0.05);两者的表达均与肾透明细胞癌不同分化程度、分期、浸润和转移有关(P﹤0.05);肾透明细胞癌中KISS-1、VEGF的表达呈显著负相关(r=-5.086,P﹤0.05)。结论 KISS-1蛋白低表达与VEGF高表达可能与肾透明细胞癌的发生及浸润转移有密切关系。Objective ToinvestigatetheexpressionsandsignificancesofKISS-1andVEGFinrenal clearcellcarcinomatissuesanditsclinicalsignificance.Methods Immunohistochemicaldetectionof31 cases of renal clear cell carcinoma and 15 patients with normal kidney tissue and protein KISS-1 and VEGF expression.Results InrenalclearcellcarcinomaandexpressionofKISS-1proteininrenaltissuesof normal positive rate were 29% and 60%,a statistically significant difference（P〈0.05）;in renal clear cell carcinoma and normal kidney tissue VEGF expression in 80.6% and 46.7%,respectively,a statistically significant difference（P〈0.05 ）;low undifferentiated,Ⅲ -Ⅳ and lymph node metastasis in human renal clear cell carcinoma of the KISS-1 expression of differentiation than high schools,respectively,secondary and no lymph node metastasis of Ⅰ-Ⅱ low and undifferentiated,phase Ⅲ -Ⅳ renal clear cell carcinoma and lymph node metastasis in the differentiation of VEGF expression level than high schools,respectively, secondary and no lymph node metastasis of I -high. And both expressions are a significant negative correlation（r=-5.086,P〈0.05）.Conclusion abnormalexpressionofKISS-1protein,VEGFmaybe associated with renal clear cell carcinoma and closely related to invasion and metastasis.

关 键 词：KISS-1 VEGF 肾透明细胞癌 蛋白表达 

分 类 号：R737.11[医药卫生—肿瘤]